198470-63-2

Usage

Uses

Used in Peptide Synthesis:
BOC-D-TYR(BZL)-OL is used as a protected amino acid in peptide synthesis for the selective deprotection and subsequent coupling reactions. The BOC (tert-butoxycarbonyl) group acts as a protecting group for the amino group of the tyrosine residue, while the benzyl group provides additional protection for the hydroxyl group of the tyrosine residue.
Used in Pharmaceutical Industry:
BOC-D-TYR(BZL)-OL is used as a key building block for the preparation of peptide and protein-based drugs. Its protected structure allows for the synthesis of complex peptide sequences with controlled selectivity and reactivity, which is crucial for the development of effective and stable pharmaceutical compounds.
Used in Academic Research:
BOC-D-TYR(BZL)-OL is used in academic research for the study of organic chemistry and biochemistry. Its unique structure and properties make it a valuable tool for understanding the synthesis, modification, and function of peptides and proteins, as well as for exploring new methods and techniques in chemical biology.

Upstream product

• 556-02-5 tyrosine 
• 300408-88-2 (R)-3-(4-benzyloxyphenyl)-2-tert-butoxycarbonylamino-propionic acid benzyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 70642-86-3 N-(tert-butoxycarbonyl)-D-tyrosine 
• 76757-90-9 N-(tert-butoxycarbonyl)-D-tyrosine methyl ester 
• 3410-66-0 D-tyrosine methyl ester 

Relevant academic research and scientific papers

Asymmetric solution-phase mixture aldol reaction using oligomeric ethylene glycol tagged chiral oxazolidinones

Sorting tags are oligomeric structures that can be used as protecting groups or chiral auxiliaries enabling solution-phase mixture syntheses of multiple tagged compounds in one pot and allowing for facile and predictable chromatographic separation of products at the end of synthetic sequences. Perfluorinated hydrocarbon and oligomeric ethylene glycol (OEG) derivatives are known classes of sorting tags. Herein we describe the preparation of OEGylated chiral oxazolidinones and their use in asymmetric solution-phase mixture aldol reactions. Through the use of such oxazolidinones based on tyrosine four different individually tagged aldol adducts were obtained as a mixture, chromatographically demixed, detagged, and it was shown that these processes gave the desired aldol products in good yield and enantioselectivity.

Ligand creation via linking - A rapid and convenient method for construction of novel supported PyOX-ligands

A novel supported amino alcohol linker was synthesized and utilized for attachment of picolinic acid derivatives onto different supports. When the resin bound molecule was further activated, the PyOX-moiety could be constructed reliably in enantiopure form. Furthermore, an efficient Pd-catalyzed modification of a picolinic acid derivative is presented.