198482-62-1

Basic information

• Product Name: 6-Deoxy-6-(2-propynyloxy)erythromycin A
• Synonyms: A-174982
• CAS NO: 198482-62-1
• Molecular Formula: C₄₀H₆₉NO₁₃
• Molecular Weight: 771.99483
• Mol File: 198482-62-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-Deoxy-6-(2-propynyloxy)erythromycin A(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Deoxy-6-(2-propynyloxy)erythromycin A(198482-62-1)
• EPA Substance Registry System: 6-Deoxy-6-(2-propynyloxy)erythromycin A(198482-62-1)

Safety Data

• Hazardous Substances Data: 198482-62-1(Hazardous Substances Data)

Upstream product

• 206997-61-7 E-2',4-O-bis(trimethylsilyl)erythromycin A 9-O-(1-isopropyloxycyclohexyl)oxime 

Downstream Products

• 365568-75-8 6-O-propargyl-2'-O-benzoyl-4''-O-benzoylerythromycin 

Relevant articles and documents

6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY

PROBLEM TO BE SOLVED: To provide 6-O-substituted ketolides with antibacterial activity, having acid stability and enhanced activity toward gram negative bacteria and macrolide resistant gram positive bacteria. SOLUTION: This invention provides 6-O-substituted erythromycin ketolide derivatives such as formula (II) and compositions comprising the compounds. [Y and Z together form a group X; X is ketone, hydroxyimino or the like; or, one of Y and Z is H and the other is hydrogen, hydroxy or the like; Ra is H, hydroxy; Rc is H or a hydroxy protective group; R is a substituted methyl group]. COPYRIGHT: (C)2015,JPOandINPIT

Synthesis and antibacterial activity of novel 6-O-substituted erythomycin A derivatives

A series of novel 6-O-substituted erythromycin A derivatives has been synthesized. Good in vitro antibacterial activity has been demonstrated for analogues incorporating a variety of structural features. The methodology disclosed is expected to find application in the design of future macrolide antibiotics that target the prevalent bacterial resistance problem. (C) 2000 Elsevier Science Ltd. All rights reserved.