1986-91-0Relevant academic research and scientific papers
Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB
Soellner, Matthew B.,Rawls, Katherine A.,Grundner, Christoph,Alber, Tom,Ellman, Jonathan A.
, p. 9613 - 9615 (2008/02/13)
A new substrate-based fragment approach for the identification of novel PTP inhibitors is presented. This method was applied to Mycobacterium tuberculosis PtpB, a promising new target for the treatment of tuberculosis. This resulted in the development of the most potent PtpB inhibitor reported to date (0.22 μM) with low molecular weight and good selectivity against a panel of other protein tyrosine phosphatases. Copyright
Synthesis of mono-and dialkylphosphates by the reactions of hydroxycompounds with the phosphorus pentaoxide under microwave irradiation
Elias, Abdelhamid,Didi, M. Amine,Villemin, Didier,Semaoune,Ouattas
, p. 2599 - 2607 (2007/10/03)
The reactions of phosphorus pentoxide with two alcohols and one phenol were performed in different conditions under microwave irradiation. The products (alkylphosphates and dialkylphosphates) were identical to those formed by classic heating and were obtained with better yields. The speed of the reaction was increased by a factor from 100 to 4000.
NMR study of the action of phophorus pentoxide on p-(1,1,3,3-tetramethylbutyl) phenol
Didi, Mohamed-Amine,Azzouz, Abdelkrim,Rodehuser, Ludwig,Dumitriu, Emil
, p. 631 - 639 (2007/10/03)
The reaction between P2O5 and p-(1,1,3,3'-tetramethylbutyl)phenol was investigated through 31P-NMR. The considered kinetic model showed that only time and, to a lesser extent, the temperature of the reaction, seem to influence the yield. The reactant mole ratio exhibits no effect upon the MOPPA:DOPPA ratio. Attempts based on a 2 3 factorial experiment design allowed to confirm these results. The tripyroesters were identified as being the longest intermediates detected by NMR. In the reaction mixture no traces of phosphoric triester (TOPPA) were detected.
