198632-19-8Relevant academic research and scientific papers
Synthesis and cardiovascular activity of new phenothiazines
Kumar, Ashok,Verma,Bhatia,Gupta, Swati,Jettly,Bajpai,Saxena,Srivastava
, p. 1 - 4 (2007/10/03)
Some new Schiff's bases substituted-benzaldehyde, 2-(2-acetyl-10H-phenothiazin-10-yl)-2-oxo-ethyl hydrazones (IVa-IVe), 2-acetyl-10-(5-substituted phenyl-2-oxo-4-thiazolidin-1-yl)-aminoacetylphenothiazines (Va-Ve), 2-acetyl-10-[(2-oxo-3-chloro-4-azetidin-1-yl) aminoacetylphenothiazines (VIa-VIe) and 1,3-disubstituted phenyl-5-[(2-acetyl-10-phenothiazin-10-yl)-2-oxo-ethyl] formazans (VIIa-VIIb) have been synthesized and were evaluated for their cardiovascular activity. Compounds IVa, IVd and IVe showed highly statistically significant changes in blood pressure, heart rate and pressor responses (Cardiovascular activity). The most active compound in our preliminary study is found to be 2,4-dichlorobenzaldehyde 2-(2-acetyl-10H-phenothiazin-10-yl)-2-oxo-ethyl hydrazone (IVa) which showed statistically significant changes in the fall of blood pressure (75.63%).
