19868-85-0

Usage

Derivative of pyrazole

This indicates that the compound is based on a pyrazole ring, which is a five-membered ring with two nitrogen atoms.

Used in organic synthesis and pharmaceutical research

This indicates that the compound is used as a building block or intermediate in the synthesis of other organic compounds, including drugs.

Potential applications in the treatment of various diseases and conditions

This suggests that the compound may have therapeutic properties and could be used in the development of new drugs for various medical conditions.

Used as a building block in the synthesis of other organic compounds

This indicates that the compound may be used in the synthesis of other organic compounds, contributing to the development of new materials and chemicals.

Upstream product

• 584-13-4 4-amino-1,2,4-triazole 
• 3994-50-1 1-methyl-4-nitropyrazole 
• 1192-21-8 5-Amino-1-methylpyrazole 
• 89607-13-6 5-bromo-1-methyl-4-nitropyrazole 

Downstream Products

• 45514-38-3 1-methyl-1H-pyrazole-4,5-diamine 

Relevant academic research and scientific papers

Free radicals in vicarious C-amination reactions of 1-methyl-4- nitropyrazole

The primary radical anions of substrate in the reactions of vicarious nucleophilic substitution of hydrogen in 1-methyl-4-nitropyrazole with 1,1,1-trimethylhydrazinium iodide and 4-amino-1,2,4-triazole in t-BuOK-DMSO were observed and identified by EPR mo

C-H Amination of Nitro Azaheterocyclic Compounds by Vicarious Nucleophilic Substitution

Various nitro azaheterocyclic compounds were subjected to C H amination by vicarious nucleophilic substitution with 4H-1,2,4-triazol-4-amine (ATA). The aminated products were characterized by NMR, mass spectroscopy, and single-crystal X-ray diffraction an

FGFR4 INHIBITORS

Methods, compounds, pharmaceutical compositions, and methods of preparing medicaments for treating hepatocellular carcinoma having an altered FGFR4 and/or FGF19 status.

FGFR4 INHIBITORS

We provide FGFR inhibitors, their salts, methods of manufacture, and methods of use.

Synthesis and SAR of novel parenteral anti-pseudomonal cephalosporins: Discovery of FR264205

We describe herein the synthesis and biological evaluation of a series of novel cephalosporins with potent activity against Pseudomonas aeruginosa. Introduction of various amino groups to the 4-position of a 3-amino-2-methylpyrazole cephalosporin 3-side c

AMINATION OF ISOMERIC BROMO-1-METHYLNITROPYRAZOLES

A method was developed for the synthesis of 5-bromo-1-methyl-4-nitropyrazole from 1-methylpyrazole.In the reaction with 25percent aqueous ammonia at 180-190 deg C, 5-bromo-1-methyl-4-nitropyrazole is readily converted to 5-amino-1-methyl-4-nitropyrazole; the production of 4-amino-1-methyl-5-nitropyrazole from 4-bromo-1-methyl-5-nitropyrazole requires the presence of a copper catalyst; under the same conditions in the amination of 4-bromo-1-methyl-3-nitropyrazole, 4-amino-1-methyl-3-nitro- and 1-methyl-3-nitropyrazoles are formed in a 2 : 3 ratio.