198703-75-2

Upstream product

• 199581-51-6 (2S,3R,4R,5R)-5-(4-Amino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-carbaldehyde 
• 198703-67-2 1-{(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-5-[(N-methyl-aminooxy)-methyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 198703-90-1 C₅₂H₅₈N₆O₁₃ 

Relevant academic research and scientific papers

The synthesis of the sixteen possible 2'-O-methyl MMI dimer phosphoramidites: Building blocks for the synthesis of novel antisense oligonucleotides

The synthesis of Methylene(methylimino) or MMI linked nucleoside dimers in all sixteen possible configurations has been accomplished via a reductive coupling of a nncleosidic aldehyde with an hydroxylamine. This has allowed us to prepare all of the necessary 2'-O-methyl MMI dimer building blocks necessary for use in an antisense motif.