19875-60-6

Basic information

• Product Name: R-(+)-LISURIDE HYDROGEN MALEATE
• Synonyms: 3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethylureamaleate(1:1);3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethyl-uremaleate(1:1);3-(9,10-didehydro-6-methylergolin-8-yl)-1,1-diethylureahydrogenmaleate;cuvalit;lisuridehydrogenmaleate;lisuridemaleate;lysenyl;lysenylbimaleate
• CAS NO: 19875-60-6
• Molecular Formula: C₄H₄O₄*C₂₀H₂₆N₄O
• Molecular Weight: 454.52
• EINECS: 243-387-3
• Mol File: 19875-60-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 200° (dec)
• Boiling Point: 603.4°Cat760mmHg
• Flash Point: 318.7°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 1.64E-14mmHg at 25°C
• Storage Temp.: Desiccate at RT
• CAS DataBase Reference: R-(+)-LISURIDE HYDROGEN MALEATE(CAS DataBase Reference)
• NIST Chemistry Reference: R-(+)-LISURIDE HYDROGEN MALEATE(19875-60-6)
• EPA Substance Registry System: R-(+)-LISURIDE HYDROGEN MALEATE(19875-60-6)

Safety Data

• Hazardous Substances Data: 19875-60-6(Hazardous Substances Data)

Usage

Description

R-(+)-LISURIDE HYDROGEN MALEATE is a chemical compound that belongs to the class of ergot alkaloids. It is a dopamine receptor agonist, meaning that it activates dopamine receptors in the brain. This property allows it to have therapeutic effects on various neurological and psychiatric conditions.

Uses

Used in Pharmaceutical Industry:
R-(+)-LISURIDE HYDROGEN MALEATE is used as a treatment for Parkinson's disease. It is utilized for improving motor symptoms and reducing the involuntary movements associated with the condition. Its mechanism of action involves the activation of dopamine receptors, which helps alleviate the symptoms of the disease.
Used in Psychiatric Treatments:
R-(+)-LISURIDE HYDROGEN MALEATE is also being investigated for its potential use in the treatment of psychiatric disorders such as schizophrenia and depression. Its effects on neurotransmitter systems, including dopamine, serotonin, and noradrenaline, may contribute to its therapeutic efficacy in these conditions.
Used in Neurotransmitter Research:
Due to its action on multiple neurotransmitter systems, R-(+)-LISURIDE HYDROGEN MALEATE is used in research to better understand the roles of these systems in various neurological and psychiatric disorders. This can lead to the development of new therapeutic approaches and a deeper understanding of the underlying mechanisms of these conditions.

InChI:InChI=1/C20H26N4O.C4H4O4/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14;5-3(6)1-2-4(7)8/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,18+;/m0./s1

Synthetic route

Conditions	Yield
With water In 1,4-dioxane at 100℃; Rate constant; Product distribution;

Downstream Products

• 18016-80-3 lisuride