198782-59-1

Basic information

• Product Name: (10E)-3-O-De(α-L-cladinose)-10-dehydro-11-dehydroxy-6-O-Methyl-erythroMycin
• Synonyms: (10E)-3-O-De(α-L-cladinose)-10-dehydro-11-dehydroxy-6-O-Methyl-erythroMycin;(10E)-3-O-De(2,6-dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)-10,11-didehydro-11-deoxy-6-O-Methyl-erythroMycin
• CAS NO: 198782-59-1
• Molecular Formula: C₃₀H₅₃NO₉
• Molecular Weight: 571.74312
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 198782-59-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 706.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 12.43±0.70(Predicted)
• CAS DataBase Reference: (10E)-3-O-De(α-L-cladinose)-10-dehydro-11-dehydroxy-6-O-Methyl-erythroMycin(CAS DataBase Reference)
• NIST Chemistry Reference: (10E)-3-O-De(α-L-cladinose)-10-dehydro-11-dehydroxy-6-O-Methyl-erythroMycin(198782-59-1)
• EPA Substance Registry System: (10E)-3-O-De(α-L-cladinose)-10-dehydro-11-dehydroxy-6-O-Methyl-erythroMycin(198782-59-1)

Safety Data

• Hazardous Substances Data: 198782-59-1(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Upstream product

• 144604-03-5 (10E)-10,11-didehydro-11-deoxy-6-O-methylerythromycin 
• 81103-11-9 clarithromycin 

Downstream Products

• 198782-60-4 (2S,3R,4S,6R)-4-(dimethylamino)-2-(((3R,4S,5S,6R,7R,9R,13S,14R,E)-14-ethyl-4,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxooxacyclotetradec-11-en-6-yl)oxy)-6-methyltetrahydro-2H-pyran-3-yl acetate 
• 160145-83-5 2'-O-acetyl-10,11-didehydro-11-deoxy-12-O-(1H-1-imidazoylcarbonyl)-3-O-descladinosyl-3-oxo-6-O-methyl-erythromycin A 
• 676536-47-3 Benzoic acid (2S,3R,4S,6R)-4-dimethylamino-2-((E)-(3R,4S,5S,6R,7R,9R,13S,14R)-14-ethyl-4,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-11-en-6-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester 

Relevant articles and documents

An Approach to Modify 14-Membered Lactone Macrolide Antibiotic Scaffolds

A ketolide derivative with (12R)-configuration was obtained via a novel ketene acetal in acidic conditions. The structure of this atypical β-keto ketene acetal intermediate within the macrocyclic system has been determined by NMR and X-ray methods. The use of basic conditions at an elevated temperature yielded new, doubly α,β-unsaturated ketone macrolide derivatives with (4E)-configuration as two conformational isomers of folded-in or folded-out conformations.