198822-79-6

Upstream product

• 4105-38-8 Tri-O-acetyluridine 
• 84500-33-4 2',3',5'-tri-O-acetyl-5-iodouridine 
• 174193-19-2 Dithiophosphoric acid O-(3-{1-[(3aR,4R,6R,6aR)-6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-propyl) ester S,S'-diphenyl ester 
• 174193-16-9 1-[(2R,3R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-5-[3-(tetrahydro-pyran-2-yloxy)-propyl]-1H-pyrimidine-2,4-dione 
• 174193-18-1 1-[(3aR,4R,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-5-(3-hydroxy-propyl)-1H-pyrimidine-2,4-dione 
• 174193-14-7 Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-{2,4-dioxo-5-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-3,4-dihydro-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 
• 174193-17-0 1-[(2R,3R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-5-(3-hydroxy-propyl)-1H-pyrimidine-2,4-dione 
• 174193-15-8 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-[3-(tetrahydro-pyran-2-yloxy)-propyl]-1H-pyrimidine-2,4-dione 
• 198822-78-5 Thiophosphoric acid O-{3-[1-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-propyl} ester S-phenyl ester 

Relevant academic research and scientific papers

Synthesis and properties of conformationally rigid cyclouridylic acids having covalent bonding linkers between the uracil 5-position and the 5′-phosphate group

Conformationally rigid cyclouridylic acid derivatives 2 and 3 having ethylene and propylene bridges, respectively, between the uracil 5-position and the 5′-phosphate group were synthesized. These intramolecularly cyclized compounds have predominantly the ribose pucker of C3′-endo and the g+ orientation around the C4′-C5′ bond. Copyright

Synthesis and properties of conformationally rigid cyclouridylic acid having a covalent bonding linker between the uracil 5-position and the 5 phosphate group

A novel cyclouridylic acid 1 having a propylene bridge between the uracil 5 position and the 5′-phosphate group was synthesized. The structure of 1 was analyzed by 1H NMR, and CD spectroscopy, which suggested that the cyclonucleotide 1 was highly stabilized in a considerably rigid g′/C3′-endo conformation with the base orientation of and. The molecular mechanics calculation of 1 gave a similar conclusion.