19886-92-1 Usage
Chemical class
Alkaloid
Parent compound
Tetrahydroisoquinoline
Natural occurrence
Found in various natural products
Functional groups
Ethyl group, methoxy group, and hydroxyl group
Core structure
Tetrahydroisoquinoline
Pharmaceutical potential
Possible use in developing drugs targeting neurological disorders
Biological activities
Potential for therapeutic applications
Research significance
Interesting molecule for medicinal chemistry and drug discovery studies
Check Digit Verification of cas no
The CAS Registry Mumber 19886-92-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,8,8 and 6 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 19886-92:
(7*1)+(6*9)+(5*8)+(4*8)+(3*6)+(2*9)+(1*2)=171
171 % 10 = 1
So 19886-92-1 is a valid CAS Registry Number.
19886-92-1Relevant articles and documents
1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES HAVING EFFECTS OF PREVENTING AND TREATING DEGENERATIVE AND INFLAMMATORY DISEASES
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Page/Page column 7, (2010/09/05)
Provided are 7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline derivatives and synthesis methods thereof. The compounds significantly inhibit the production of nitrogen monoxide (NO) and superoxide in an activated microglial cell and expressions of TNF-α, IL-1β inducive NO synthase and cyclooxygenase-2 genes. They also prevent NF-kB shift to a nucleus, decrease reactive oxygen species (ROS), inhibit expression of GTP cyclohydrolase I gene and over-production of tetrahydrobiopterin (BH4), and protect dopaminergic neurons from injury due to activated microglial cells. Consequently, the compounds are effective in treating inflammatory and neurodegenerative diseases.
