198877-45-1 Usage
General Description
2,5-Piperazinedione, 1,4-dimethyl-3-methylene, also known as nitisinone, is a chemical compound used as a medication to treat hereditary tyrosinemia type 1. It works by inhibiting an enzyme involved in the production of tyrosine, an amino acid that can build up to toxic levels in individuals with the condition. Nitisinone is available as a tablet and is typically taken once daily. It has been shown to be effective in reducing the levels of toxic metabolites in the body and improving the symptoms of hereditary tyrosinemia type 1. Side effects of nitisinone may include liver toxicity, eye problems, and joint pain, and it is important for individuals taking the medication to be closely monitored by a healthcare professional.
Check Digit Verification of cas no
The CAS Registry Mumber 198877-45-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,8,8,7 and 7 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 198877-45:
(8*1)+(7*9)+(6*8)+(5*8)+(4*7)+(3*7)+(2*4)+(1*5)=221
221 % 10 = 1
So 198877-45-1 is a valid CAS Registry Number.
198877-45-1Relevant articles and documents
The synthetic versatility of alkoxycarbonyl- and hydroxymethyl-piperazine- 2,5-diones
Chai, Christina L.L.,Elix, John A.,Huleatt, Paul B.
, p. 8722 - 8739 (2007/10/03)
Alkoxycarbonylpiperazine-2,5-diones are versatile precursors for the α-functionalisation of piperazine-2,5-diones. The alkoxycarbonyl group activates the α-carbon position to alkylation reactions and this provides a mild and selective method for the extension of the carbon framework of piperazine-2,5-diones. In addition, the alkoxycarbonyl group can be converted to the carboxy group, which in turn can be 'deleted' or manipulated for the installation of carbon and/or heteroatom substituents where desired, the latter via N-acyliminium chemistry. We also demonstrate that hydroxymethylpiperazine-2, 5-diones complement carboxypiperazinediones as precursors for the generation of N-acyliminium ions.
