198903-86-5

Basic information

• Product Name: N-[(1S,2S)-1-benzyl-2-hydroxy-3-(2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-1-[4-(1,3-thiazol-5-yl)benzyl]hydrazino)propyl]-N~2~-(methoxycarbonyl)-L-valinamide
• Synonyms: butanoic acid, 2-[(methoxycarbonyl)amino]-3-methyl-, 2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]amino]-4-phenylbutyl]-2-[[4-(5-thiazolyl)phenyl]methyl]hydrazide, (2S)-; N-[(2S,3S)-3-hydroxy-4-(2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-1-[4-(1,3-thiazol-5-yl)benzyl]hydrazinyl)-1-phenylbutan-2-yl]-N~2~-(methoxycarbonyl)-L-valinamide
• CAS NO: 198903-86-5
• Molecular Formula: C₃₄H₄₆N₆O₇S
• Molecular Weight: 682.83
• Mol File: 198903-86-5.mol
• Article Data: 2

Chemical Properties

• Density: 1.23g/cm³
• Refractive Index: 1.573
• CAS DataBase Reference: N-[(1S,2S)-1-benzyl-2-hydroxy-3-(2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-1-[4-(1,3-thiazol-5-yl)benzyl]hydrazino)propyl]-N~2~-(methoxycarbonyl)-L-valinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1S,2S)-1-benzyl-2-hydroxy-3-(2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-1-[4-(1,3-thiazol-5-yl)benzyl]hydrazino)propyl]-N~2~-(methoxycarbonyl)-L-valinamide(198903-86-5)
• EPA Substance Registry System: N-[(1S,2S)-1-benzyl-2-hydroxy-3-(2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-1-[4-(1,3-thiazol-5-yl)benzyl]hydrazino)propyl]-N~2~-(methoxycarbonyl)-L-valinamide(198903-86-5)

Safety Data

• Hazardous Substances Data: 198903-86-5(Hazardous Substances Data)

Upstream product

• 198904-49-3 N'-[(2S,3S)-2-Hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-N'-(4-thiazol-5-yl-benzyl)-hydrazinecarboxylic acid tert-butyl ester 
• 198904-45-9 N'-[(2S,3S)-2-Hydroxy-4-phenyl-3-(2,2,2-trifluoro-acetylamino)-butyl]-N'-(4-thiazol-5-yl-benzyl)-hydrazinecarboxylic acid tert-butyl ester 
• 198904-46-0 1-[4-(thiazol-5-yl)-phenyl]-4(S)-hydroxy-2-(tert-butoxycarbonyl)amino-5(S)-amino-6-phenyl-2-azahexane 
• 198904-42-6 N-1-(tert-butyloxycarbonyl)-N-2-[4-(thiazol-5-yl)benzyl]hydrazine 
• 198904-40-4 4-(thiazol-5-yl)benzaldehyde 
• 1122-91-4 4-bromo-benzaldehyde 
• 111398-44-8 N-methoxycarbonyl-L-valine 
• 198904-50-6 ((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N-(4-thiazol-5-yl-benzyl)-hydrazino]-propylcarbamoyl}-2-methyl-propyl)-carbamic acid methyl ester 

Relevant articles and documents

ANTIVIRALLY ACTIVE HETEROCYCLIC AZAHEXANE DERIVATIVES

There are described compounds of formula I*, STR1 wherein R. sub.1 is lower alkoxycarbonyl,R 2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R. sub.3 is phenyl that is unsubstituted or substituted by one or more lower alkoxy radicals, or C 4-C 8 cycloalkyl,R. sub.4 is phenyl or cyclohexyl each substituted in the 4-position by unsaturated heterocyclyl that is bonded by way of a ring carbon atom, has from 5 to 8 ring atoms, contains from 1 to 4 hetero atoms selected from nitrogen, oxygen, sulfur, sulfinyl (--SO--) and sulfonyl (--SO 2--) and is unsubstituted or substituted by lower alkyl or by phenyl-lower alkyl,R 5, independently of R 2, has one of the meanings mentioned for R 2, andR 6, independently of R. sub.1, is lower alkoxycarbonyl,or salts thereof, provided that at least one salt-forming group is present. The compounds are inhibitors of retroviral aspartate protease and can be used, for example, in the treatment of AIDS. They exhibit outstanding pharmacodynamic properties.