198904-31-3 Usage
Description
Atazanavir is an inhibitor of human immunodeficiency virus type 1 (HIV-1) protease, an
enzyme that is essential for the processing of Gag and Gag-Pol polyproteins into structural
and enzymatic proteins required for viral replication. It has a similar pharmacophore motif
to the other six widely marketed HIV protease inhibitors, most of which are based upon a
hydroxyethylamine template. Uniquely, it possesses an aza-peptide motif but maintains
many similar pharmacophore elements including lipophilic moieties that presumably bind
to S2, S1, S′1
, and S′2
positions. Atazanavir is pseudo-symmetric about the central template,
incorporating D-tert-Leucine at both termini. This compound is synthesized in about seven
steps, with a key coupling of the chiral epoxide (derived from phenylalanine and imparting
one chiral center) and N-tert-boc-N′-(4-[2-pyridyl]benzyl)hydrazine. Removal of both
tert-Boc groups and double acylation with methoxycarbonyl-tert-Leucine provides the
product. Another synthesis of atazanavir entails ten steps and utilizes α-(tert-bocamino)
phenylpropanal as a chiral intermediate. It is a potent inhibitor of indinavir-resistant
and saquinavir-resistant strains of HIV-1 (IC50=0.03–0.1 and 0.04–0.1 μM,
respectively). In 300 patients who had failed previous treatment, atazanavir (400 mg
once daily) was compared to lopinavir (400 mg twice daily) and ritonavir (100 mg); both
arms additionally receiving two non-reverse transcriptase inhibitors. After 24 weeks, HIV
RNA levels of ＜400 copies/mL were noted in 61% of patients receiving atazanavir and
81% of those taking lopinavir/ritonavir. After 96 weeks of therapy with atazanavir, HIV
RNA copy levels were found to be ＜400 and ＜50 in 80 and 58% of patients, respectively.
A study of the cross-resistance profile relative to other protease inhibitors using a panel of
551 clinical isolates (without prior atazanavir exposure but with cross-resistance to one or
two other protease inhibitors; the majority had resistance to nelfinavir) showed that greater
than 80% retained susceptibility to atazanavir. All of the resistant isolates from patients
taking atazanavir had an I50 L substitution. The recommended dosage of atazanavir is
400 mg once daily. It has a mean half-life range of 7.9–6.5 h with about 60%
bioavailability and moderate plasma protein binding (86% albumin and 89% alpha-1-
acid glycoprotein (AAG)). Atazanavir was well tolerated in clinical studies and it
displayed minimal lipid modulation when tested in combination with two non-reverse
transcriptase inhibitors. Atazanavir had no effect on total cholesterol, low-density
lipoprotein, and triglyceride levels when compared with other protease inhibitors that
caused sustained elevations in these lipid levels.
Chemical Properties
Crystalline Solid
Uses
Different sources of media describe the Uses of 198904-31-3 differently. You can refer to the following data:
1. Atazanavir is a novel azapeptide protease inhibitor (PI)
2. Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral.
3. Atazanavir is an inhibitor of HIV-1 protease (EC50 = 2.6 nM). In isolated cells, it has additive to moderately synergistic antiviral effects when combined with other antiretroviral drugs. As a result, it is commonly used in vivo in combination therapy for HIV-1 infection. Atazanavir competitively inhibits UDP-gluronosyltransferase, which conjugates bilirubin for clearance, leading to hyperbilirubinemia in a significant portion of those receiving atazanavir therapy.
Definition
ChEBI: A heavily substituted carbohydrazide that is an antiretroviral drug of the protease inhibitor (PI) class used to treat infection of human immunodeficiency virus (HIV).
Brand name
Reyataz
(Bristol-Myers Squibb).
Acquired resistance
Mutations at positions 50 (I50L), 84 (I84V) and 88 (N88S)
of the protease gene are associated with resistance.
General Description
Atazanavir is an antiretroviral agent that has been approvedby the FDA for use in combination with other anti-RTagents for the treatment of HIV infections. The drug is alwaysused in combination with RT inhibitors.
Pharmaceutical Applications
An azapeptide formulated as the sulfate for oral use.
Biochem/physiol Actions
Atazanavir is an antiviral HIV protease inhibitor.
Mechanism of action
Atazanavir is dosed orally once daily, thus reducing "pill burden," and it appears to have minimal impact
on lipid parameters but does increase total bilirubin. The drug is well absorbed when administered orally
with food (bioavailability, ~68%). The drug is highly bound to plasma protein (86%) and is metabolized by
CYP3A isoenzyme. Atazanavir is a moderate inhibitor of CYP3A, and potential drug–drug interactions are
possible with CYP3A inhibitors and inducers.
Pharmacokinetics
Oral absorption: c. 68%
Cmax 400 mg once daily: c. 3.15 μg/L
300 mg + ritonavir 100 mg once daily: c. 4.47 μg/L
Cmin 400 mg once daily: c. 0.27 μg/L
300 mg + ritonavir 100 mg once daily: c. 0.65 μg/L
Plasma half-life: c. 8.6 h (300 mg+ ritonavir
100 mg)
Volume of distribution: c. Not known/available
Plasma protein binding: c. 86%
Absorption
Administration with food enhances bioavailability and reduces pharmacokinetic variability. Absorption is dependent on gastric pH. It should be given separately from proton-pump inhibitors or H2-receptor antagonists. Buffered or entericcoated formulations should be given (with food) 2 h before or 1 h after co-administration of didanosine.
Distribution
It penetrates moderately well into the CNS. The semen:plasma ratio is 0.11–4.42. It is distributed into breast milk.
Metabolism
It is extensively metabolized by CYP3A4. Administration with ritonavir prevents metabolization and enhances the pharmacokinetic profile.
Excretion
Following a single 400 mg dose, 79% and 13% of the dose was recovered in the feces and urine, respectively. It should be used with caution in the presence of mild hepatic impairment and should not be used in patients with more severe hepatic impairment.
Clinical Use
Treatment of HIV infection (in combination with other antiretroviral drugs)
Side effects
The most common adverse reactions (≥2%) are nausea, jaundice/
scleral icterus, rash, headache, abdominal pain, vomiting,
insomnia, peripheral neurological symptoms, dizziness, myalgia,
diarrhea, depression and fever.
Drug interactions
Potentially hazardous interactions with other drugs
Anti-arrhythmics: possibly increased levels of
amiodarone and lidocaine.
Antibacterials: concentration of both drugs
increased when given with clarithromycin; rifabutin
concentration increased - reduce dose of rifabutin;
rifampicin reduces atazanavir concentration - avoid;
avoid with telithromycin in severe renal and hepatic
impairment.
Anticoagulants: avoid with apixaban and
rivaroxaban.
Antidepressants: concentration reduced by St John’s
wort - avoid.
Antifungals: concentration increased by
posaconazole; concentration of voriconazole
increased or decreased, concentration of atazanavir
also reduced.
Antimalarials: avoid with artemether/lumefantrine;
may increase quinine concentration.
Antipsychotics: possibly inhibits metabolism of
aripiprazole - reduce dose of aripiprazole; possibly
increased concentration of pimozide and quetiapine
- avoid.
Antivirals: concentration reduced by boceprevir;
concentration of daclatasvir increased, reduce dose
of daclatasvir; absorption reduced by didanosine
tablets; concentration reduced by efavirenz -
avoid; concentration of elvitegravir increased
when atazanavir boosted with ritonavir - reduce
elvitegravir dose; concentration possibly reduced by
nevirapine - avoid; concentration of paritaprevir
increased; increased risk of ventricular arrhythmias
with saquinavir - avoid; concentration reduced
by tenofovir and tenofovir concentration possibly
increased; avoid with indinavir; concentration
of maraviroc increased, consider reducing
dose of maraviroc; possibly reduces telaprevir
concentration, also concentration of atazanavir
increased; concentration of tipranavir increased,
also concentration of atazanavir reduced; avoid
with elbasvir/grazoprevir, increased grazoprevir
concentration.
Anxiolytics and hypnotics: possibly increases
concentration of midazolam - avoid with oral
midazolam.
Calcium-channel blockers: concentration of
diltiazem increased - reduce dose of diltiazem;
possibly increased verapamil concentration.
Ciclosporin: possibly increased concentration of
ciclosporin. Colchicine: possibly increases risk of colchicine
toxicity, avoid in hepatic or renal impairment.
Cytotoxics: possibly increases concentration of
axitinib, reduce dose of axitinib; possibly increases
concentration of bosutinib, avoid or reduce dose;
possibly increases concentration of crizotinib and
everolimus - avoid; avoid with cabazitaxel and
pazopanib; concentration of ibrutinib possibly
increased, reduce dose of ibrutinib; possibly inhibits
metabolism of irinotecan - increased risk of toxicity.
Dapoxetine: avoid concomitant use, increased risk of
toxicity.
Ergot alkaloids: possibly increased concentration of
ergot alkaloids - avoid.
Orlistat: absorption possibly reduced by orlistat.
Ranolazine: possibly increases ranolazine
concentration - avoid.
Sildenafil: possibly increased side effects of sildenafil.
Sirolimus: possibly increased concentration of
sirolimus.
Statins: avoid with simvastatin - increased risk of
myopathy; possibly increased risk of myopathy with atorvastatin, pravastatin and rosuvastatin - reduce
rosuvastatin dose.
Tacrolimus: possibly increased concentration of
tacrolimus.
Ticagrelor: possibly increases concentration of
ticagrelor - avoid.
Ulcer-healing drugs: concentration significantly
reduced by omeprazole and esomeprazole and
possibly other proton pump inhibitors - avoid;
concentration possibly reduced by histamine H2
antagonists.
Metabolism
Atazanavir is principally metabolised by CYP3A4
isozyme to oxygenated metabolites. Metabolites are
then excreted in the bile as either free or glucuronidated
metabolites. Additional minor metabolic pathways consist
of N-dealkylation and hydrolysis. Two minor metabolites
of atazanavir in plasma have been characterised. Neither
metabolite demonstrated in vitro antiviral activity.
Following a single 400 mg dose of [14C]-atazanavir, 79%
and 13% of the total radioactivity was recovered in the
faeces and urine, respectively. Unchanged drug accounted
for approximately 20% and 7% of the administered dose
in the faeces and urine, respectively.
Check Digit Verification of cas no
The CAS Registry Mumber 198904-31-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,8,9,0 and 4 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 198904-31:
(8*1)+(7*9)+(6*8)+(5*9)+(4*0)+(3*4)+(2*3)+(1*1)=183
183 % 10 = 3
So 198904-31-3 is a valid CAS Registry Number.
InChI:InChI=1/C38H52N6O7/c1-37(2,3)31(41-35(48)50-7)33(46)40-29(22-25-14-10-9-11-15-25)30(45)24-44(43-34(47)32(38(4,5)6)42-36(49)51-8)23-26-17-19-27(20-18-26)28-16-12-13-21-39-28/h9-21,29-32,45H,22-24H2,1-8H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47)/t29-,30?,31?,32+/m0/s1
198904-31-3Relevant articles and documents
Method for synthesis of atazanavir
-
Paragraph 0049; 0050; 0052, (2018/04/01)
The invention discloses a method for synthesis of atazanavir. The method comprises that a compound methyl (S)-1-((S)-2-ethoxyethyl-1-phenylethane-2-yl-amino)-3, 3-dimethyl-1-carbonylbutane-2-yl-carbamate shown in the formula V and a compound N-1-[N-(methoxycarbonyl)-L-tertiary leucine]-N-2-[4-(2-pyridyl)-benzyl]hydrazine shown in the formula VIII undergo a nucleophilic substitution reaction in anorganic solvent to produce a compound 1-[4-(2-pyridyl)phenyl]-5(S)-2, 5-bis{[N-(methoxycarbonyl)-L-tertiary leucine]amino}-4(S)-hydroxy-6-phenyl-2-azahexane VIII shown in the formula IX, wherein the compound shown in the formula IX is atazanavir. The method utilizes raw materials having a wide raw material source, the product is easy to purify, a cost is low, the synthesis processes are simple, the operation is simple, the process is simple, special requirement on equipment is avoided and large-scale production feasibility is realized.
Method for preparing anti-AIDS drug-Atazanavir monomer
-
Paragraph 0022; 0023; 0024; 0025, (2017/06/02)
The invention discloses a method which is used for preparing an Atazanavir monomer and applied in the technical field of drug synthesis. The method comprises the steps that N-methoxycarbonyl-L-tertiary leucine and 1-[4-(pyridine-2-yl)-phenyl]-4(S)-hydroxyl-5(S)-2,5-diamido-6-phenyl-2-aza-hexane are subjected to an amidation reaction by taking HATU as a condensing agent under the condition of organic alkali and an organic solvent, certain aftertreatment is conducted, and then the Atazanavir monomer is obtained. According to the method, the synthetic yield of Atazanavir is increased, the purity is high, and the cost of raw materials is effectively reduced; meanwhile, the reaction time is short, material putting is easy, nitrogen protection is not needed, the material putting temperature can be properly controlled, by-products of HATU can be washed off more easily, the preparation time is greatly shortened, the working efficiency is improved, and therefore the method is suitable for industrial production.
Method for synthesizing atazanavir
-
Paragraph 0012; 0017, (2017/09/13)
The invention discloses a method for synthesizing atazanavir. The method comprises the following steps: performing nucleophilic substitution reaction on N-1-(t-butyloxycarboryl)-N-2-[4-(2-pyridyl) benzylidene]-hydrazine and (3S)-3-(t-butyloxycarboryl) amino-1-chlorine-4-phenyl-2-butanone, so as to obtain a compound III; removing a protection group of the compound III, performing condensation reaction on N-methoxycarbonyl-L-tertiary leucine, so as to obtain a compound IV; performing reduction reaction on the compound IV, thereby obtaining a final product, namely atazanavir. The method disclosed by the invention has the advantages of being gentle in reaction condition, high in security, simple and convenient to operate, simple in purification treatment on final products, high in purity, stable in quality, easy in raw material obtaining, low in price, high in total yield and the like, the total cost is greatly lowered, and the method is applicable to large-scale industrial production requirements.
