19891-85-1Relevant articles and documents
Thompson,Bowers
, p. 845,847 (1968)
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Jones,Meakins
, (1941)
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Design and synthesis of new lupeol derivatives and their α-glucosidase inhibitory and cytotoxic activities
Phan, Hoang-Vinh-Truong,Duong, Thuc-Huy,Pham, Duc-Dung,Pham, Hoang-Anh,Nguyen, Van-Kieu,Nguyen, Thi-Phuong,Nguyen, Huu-Hung,Nguyen, Ngoc-Hong,Sam-ang, Pornpat,Phontree, Kiettipum,Sichaem, Jirapast
, p. 1 - 7 (2020/05/13)
A series of lupeol derivatives 2, 2a-2f, 2a-2h, 3a-3e, and 4a-4b were designed, synthesised and evaluated for their α-glucosidase inhibitory and cytotoxic activities. Among synthetic derivatives, lupeol analogues 2b and 2e containing a benzylidene chain exhibited the best activity against α-glucosidase and superior to the positive agent with the IC50 values of 29.4 ± 1.33 and 20.1 ± 0.91 μM, respectively. Lupeol analogues 2d and 3a showed weak cytotoxicity against K562 cell line with the IC50 values of 76.6 ± 2.40 and 94.4 ± 1.51 μM, respectively.
Side chain oxidation of lupeol: A reinvestigation
Roy, Kamal,Bhaduri, A. P.
, p. 823 - 824 (2007/10/03)
Oxidation of lupeol with m-chloroperbenzoic acid yields lup-20-norketone-3β-ol (6), lup-20(29)-ene-3β,30-diol (7) and lup-20-al-3β-ol (8).Formation of the compounds 7 and 8 from lupeol is being reported for the first time.