19895-44-4

Basic information

• Product Name: 1-phenyl-3-propan-2-ylurea
• Synonyms: urea, N-(1-methylethyl)-N'-phenyl-
• CAS NO: 19895-44-4
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.231
• Mol File: 19895-44-4.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 261.2°C at 760 mmHg
• Flash Point: 100.8°C
• Density: 1.082g/cm³
• Vapor Pressure: 0.0117mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 1-phenyl-3-propan-2-ylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-3-propan-2-ylurea(19895-44-4)
• EPA Substance Registry System: 1-phenyl-3-propan-2-ylurea(19895-44-4)

Safety Data

• Hazardous Substances Data: 19895-44-4(Hazardous Substances Data)

Usage

Use

Antihistamine and antiemetic medication

Mechanism of action

Blocks the action of histamine in the body

Symptoms reduced

Itching, runny nose, sneezing

Additional effects

Anti-nausea and sedative

Conditions treated

Motion sickness, allergic reactions, sedation for adults and children

Administration methods

Oral, rectal, or injection

Combination with other medications

Yes, for added therapeutic benefits

Upstream product

• 62-53-3 aniline 
• 1795-48-8 Isopropyl isocyanate 
• 64-17-5 ethanol 
• 75-31-0 isopropylamine 
• 6320-72-5 4-nitrophenyl-N-phenyl carbamate 
• 201230-82-2 carbon monoxide 
• 98-95-3 nitrobenzene 
• 55-21-0 benzamide 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 114379-10-1 3-isopropyl-1,4,2-dioxazole-5-one 
• 691-60-1 N-isopropylurea 
• 103-71-9 phenyl isocyanate 
• 64-10-8 phenyl carbamate 

Downstream Products

• 2603-10-3 N-phenyl methyl carbamate 
• 130647-40-4 2-Diethylamino-1-isopropyl-3-phenyl-[1,3,2]diazaphosphetidin-4-one 
• 75-31-0 isopropylamine 
• 62-53-3 aniline 
• 100075-58-9 2-(3-Isopropyl-ureido)-benzoic acid methyl ester 
• 69777-53-3 isopropylcarbamic acid 
• 78326-57-5 C₁₀H₁₃N₃O₂ 
• 14041-89-5 N-isopropyl-N'-phenylcarbodiimide 
• 791-28-6 Triphenylphosphine oxide 

Relevant articles and documents

Reactions of N-isopropyl-N'-phenylcarbodiimide with the chlorides of benzoic, oxalic, and squaric acid

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A Fe3O4?SiO2/Schiff Base/Pd Complex as an Efficient Heterogeneous and Recyclable Nanocatalyst for One-Pot Domino Synthesis of Carbamates and Unsymmetrical Ureas

A palladium-catalyzed domino method for the direct synthesis of carbamates and ureas has been developed by using readily available and economical starting materials (aryl halide, carbon monoxide, sodium azide, amines and alcohols) in a one-pot approach. The domino process underwent carbonylation, Curtius rearrangement, and nucleophilic addition. This protocol provides a step-economical and highly efficient reaction to access the wide range of valuable carbamates, symmetrical and unsymmetrical ureas with high yields under remarkable mild reaction conditions that are important factors in pharmaceutical science, biochemistry and agricultural industries. Furthermore, the magnetically recoverable nanocatalyst (Fe3O4?SiO2/Pd(II)) can be conveniently and swiftly recycled using external magnet and reused at least for seven times without noticeable loss of its catalytic activity.

Synthesis and SAR studies of potent H+/K+-ATPase and anti-inflammatory activities of symmetrical and unsymmetrical urea analogues

A sequence of symmetrical and unsymmetrical urea derivatives 1–24 were synthesized and characterized by standard spectroscopic techniques. The synthesized analogues were tested for their in vitro H+/K+-ATPase and anti-inflammatory activities. The majority of the compounds showed outstanding activity, compared to that of omeprazole and indomethacin, usual standard drugs of antiulcer and anti-inflammatory, respectively. In particular, hydroxy, methyl, and methoxy derivatives 13–24 were the most active compounds possessing a significant amplify for diverse substituents on the benzene ring thus, contributing positively to gastric ulcer inhibition. Compounds 1–3 and 22–24 showed excellent anti-inflammatory activity due to the presence of electron-withdrawing groups (Cl and F) on the molecule.

The use of aqueous potassium dichloroiodate for the synthesis of ureas

We report a straightforward and efficient reaction protocol for the syntheses of substituted ureas via treatment of thioureas with aqueous potassium dichloroiodate (KICl2). By tuning the reaction condition, thioureas bearing activated N-aryl substituents may undergo either selective oxidation or sequential oxidation and iodination, forming iodoaryl ureas in the latter case.