198958-88-2

Basic information

• Product Name: 3(S)-[1-[3-(4-Piperidinyl)propionyl]piperidin-3(R)-ylcarboxamido]-3-(3-pyridyl)propionic acid
• Synonyms: Elarofiban; RWJ-53308; (3S)-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]-3-(pyridin-3-yl)propanoic acid
• CAS NO: 198958-88-2
• Molecular Formula: C₂₂H₃₂N₄O₄
• Molecular Weight: 416.5139
• Mol File: 198958-88-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 719.5°C at 760 mmHg
• Flash Point: 388.9°C
• Density: 1.203g/cm³
• Vapor Pressure: 1E-21mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: 3(S)-[1-[3-(4-Piperidinyl)propionyl]piperidin-3(R)-ylcarboxamido]-3-(3-pyridyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3(S)-[1-[3-(4-Piperidinyl)propionyl]piperidin-3(R)-ylcarboxamido]-3-(3-pyridyl)propionic acid(198958-88-2)
• EPA Substance Registry System: 3(S)-[1-[3-(4-Piperidinyl)propionyl]piperidin-3(R)-ylcarboxamido]-3-(3-pyridyl)propionic acid(198958-88-2)

Safety Data

• Hazardous Substances Data: 198958-88-2(Hazardous Substances Data)

Upstream product

• 163343-71-3 (R)-piperidine-3-carboxylic acid ethyl ester*l-tartaric acid 
• 51052-79-0 3-(4-piperidinyl)propionic acid hydrochloride 
• 63845-33-0 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoic acid 
• 25137-01-3 (R)-ethyl nipecotate 
• 5337-79-1 3-(4-pyridinyl)-2-propenoic acid 
• 1822-32-8 3-(4-piperidyl)propionic acid 
• 169498-29-7 (R)-1-[3-(1-benzyloxycarbonyl-4-piperidyl)propionyl]-3-piperidinecarboxylic acid 
• 71962-74-8 Ethyl nipecotate 
• 252989-40-5 (S)-3-[((R)-Piperidine-3-carbonyl)-amino]-3-pyridin-3-yl-propionic acid methyl ester 
• 223697-42-5 N-Boc-3-(4-piperidinepropionyl)-(R)-(-)-nipecotyl-[(S)-3-amino-3-(3-pyridyl)]propionic acid 
• 223697-40-3 4-{3-[(R)-3-((S)-2-Methoxycarbonyl-1-pyridin-3-yl-ethylcarbamoyl)-piperidin-1-yl]-3-oxo-propyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 198959-53-4 methyl (S)-3-amino-3-pyridin-3-ylpropionate 

Relevant articles and documents

A Practical Synthesis of the Platelet Fibrinogen Antagonist, Elarofiban

Elarofiban is a novel, nonpeptide, orally active fibrinogen receptor antagonist useful for the treatment of platelet mediated thrombotic disorders (Costanzo, M. J.; Hoekstra, W. J.; Maryanoff, B. E. WO, 97/41102,1997). Herein we describe the process research that was carried out for the synthesis of elarofiban that eventually led to the development of a safe and cost-effective commercial scale process.