198962-82-2

Upstream product

• 646-07-1 4-Methylpentanoic acid 
• 171562-32-6 N-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-4-methylbenzenesulfonamide 
• 7480-35-5 (1S,2R)-1-amino-2-indanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 198962-95-7 (2S,3R)-5-Benzyloxy-3-hydroxy-2-isobutyl-pentanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)-indan-2-yl ester 
• 198963-01-8 (2S,3S)-3-Hydroxy-2-isobutyl-5-methyl-hexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)-indan-2-yl ester 
• 540770-17-0 (2S,3S,1'S,2'R)-1'-tosylaminoindan-2'-yl 6,6,6-trichloro-3-hydroxy-2-isobutylhexanoate 
• 557111-33-8 (1S,2R)-N-[2,3-dihydro-2-((2S,3S)-(E)-3-hydroxy-5-phenyl-2-(isobutyl)-1-oxopent-4-enoxy)inden-1-yl]-4-methylbenzenesulfonamide 
• 1228119-07-0 (1S,2R)-N-[2,3-dihydro-2-((2S,3R)-2-isobutyl-3-hydroxy-4-(N-Boc-(R)-pyrrolidin-2-yl)-1-oxobutoxy)inden-1-yl]-4-methylbenzene sulfonamide 
• 1228119-08-1 (1S,2R)-N-[2,3-dihydro-2-((2S,3S)-2-isobutyl-3-hydroxy-4-(N-Boc-(R)-pyrrolidin-2-yl)-1-oxobutoxy)inden-1-yl]-4-methylbenzene sulfonamide 
• 198962-93-5 (1S,2R)-cis-N-(2,3-dihydro-2-[(2S,3S)-3-hydroxy-2-(isobutyl)-4-(phenylmethoxy)-1-oxobutoxy]inden-1-yl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Asymmetric total synthesis of the gastroprotective microbial agent AI-77-B

An enantioselective total synthesis of the pseudopeptide microbial agent AI-77-B, which has shown potent antiulcerogenic properties, is described. The synthesis is convergent and involves the assembly of a dihydroisocoumarin fragment and a hydroxy amino acid. The dihydroisocoumarin derivative was synthesised by means of a Diels-Alder reaction between 1-methoxy-1,3-cyclohexadiene and an alkynyl ester derivative as the dienophile. The alkynyl ester was obtained stereoselectively by two different synthetic routes: (1) A stereoselective allylation of leucinal, and (2) a titanium enolate-mediated anti-aldol reaction with trichlorobutyraldehyde, a novel homopropargylaldehyde equivalent. The stereocentres of the hydroxy amino acid moiety were generated through a titanium enolate-mediated syn-aldol reaction, Curtius rearrangement, and application of Dondoni's aldehyde homologation. Condensation of the dihydroisocoumarin and hydroxy amino acid moieties and subsequent removal of the protecting groups furnished optically active AI-77-B. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

Solid-phase synthesis of HTLV-1 protease inhibitors containing hydroxyethylamine dipeptide isostere

An efficient method has been developed for the first solid-phase synthesis of HTLV-1 protease inhibitors that contain hydroxyethylamine isostere as a transition-state mimetic. The synthetic procedure was designed to allow the evaluation of stereostructure

Ester derived titanium enolate aldol reaction: Highly diastereoselective synthesis of syn- and anti-aldols

Aldol reactions of bidentate aldehydes and cis-1-arylsulfonamido-2-indanyl ester derived titanium enolates proceed with excellent syn-diastereoselectivities and good to excellent isolated yields.