199003-22-0

Usage

Uses

Used in Organic Synthesis:
1-Boc-4-(hydroxyMethyl)pyrazole is used as a building block for the synthesis of complex organic molecules, particularly in the pharmaceutical and agrochemical industries. Its Boc protecting group allows for selective manipulation of the compound's reactivity, facilitating the synthesis of biologically active molecules.
Used in Pharmaceutical Industry:
1-Boc-4-(hydroxyMethyl)pyrazole is used as a key intermediate in the development of new pharmaceutical compounds. Its unique structure and reactivity make it a valuable component in the synthesis of drugs with potential therapeutic applications.
Used in Agrochemical Industry:
1-Boc-4-(hydroxyMethyl)pyrazole is employed as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its versatility and reactivity contribute to the development of effective and targeted agrochemical products.

Upstream product

• 37622-90-5 4-ethoxycarbonylpyrazole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 25222-43-9 (1H-pyrazol-4-yl)-methanol 
• 405103-00-6 ethyl (1-tert-butyloxycarbonyl)pyrazole-4-carboxylate 

Downstream Products

• 530144-72-0 tert-butyl 4-(bromomethyl)-1H-pyrazole-1-carboxylate 
• 821767-61-7 tert-butyl 4-formyl-1H-pyrazole-1-carboxylate 
• 405100-01-8 5-benzyloxy-N-(4-isopropylphenyl)-N-[(pyrazol-4-yl)methyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide 

Relevant academic research and scientific papers

Compounds and methods of use

Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X1, X2, X3, X4, Y, A, L1, L2, R1, R2, R5, m and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

BIARYL DERIVATIVE AS GPR120 AGONIST

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE

The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE

The present invention provides compounds of Formula (I). wherein A and Z are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and may be useful for for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.

2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG

The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.

OPTICALLY ACTIVE TETRAHYDRONAPHTHALENE DERIVATIVE

A compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate thereof or a solvate thereof, which shows not only a C5a receptor antagonistic activity but also high activity in the biological availability, as

NOVEL AMIDE DERIVATIVES AND MEDICINAL USE THEREOF UGS

The present invention relates to an amide derivative of the formula (1), having a C5a receptor antagonistic action wherein each symbol is as defined in the specification. The above-mentioned amide derivative, an optically active form thereof and a pharmaceutically acceptable salt thereof are promising as an agent for the treatment or prophylaxis of diseases or syndromes caused by inflammation caused by C5a [e.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis and pancreatitis and the like) due to activation of leukocytes caused by ischemia reperfusion, trauma, burn, surgical invasion and the like]. Moreover, they are useful as a therapeutic or prophylactic agent for the infectious diseases caused by bacteria and virus that invade via a C5a receptor.