199003-54-8Relevant academic research and scientific papers
N,N-dibenzyl formamide dimethyl acetal and N,N-dibenzyl chloromethylene iminium chloride: Two complementary reagents for the protection of primary amines as N,N-dibenzyl formamidines
Vincent, Stephane,Lebeau, Luc,Mioskowski, Charles
, p. 167 - 174 (1999)
Two complementary procedures are described for the preparation of N,N- dibenzyl formamidines from primary amines in high yield. The primary amine protective group can be easily introduced on polyhydroxylated molecules and is removable either by hydrolysis
Potent Nonclassical Nucleoside Antiviral Drugs Based on the N,N-Diarylformamidine Concept
Anastasi, Carole,Hantz, Olivier,De Clercq, Erik,Pannecouque, Christophe,Clayette, Pascal,Dereuddre-Bosquet, Nathalie,Dormont, Dominique,Gondois-Rey, Fran?oise,Hirsch, Ivan,Kraus, Jean-Louis
, p. 1183 - 1192 (2007/10/03)
New formamidine-3TC (3TC = 2′,3′-dideoxy-3′-thiacytidine) analogues have been synthesized through various methods, and their antiviral activities (HIV, HBV) have been evaluated in vitro. Anti-HIV-1 in acutely infected MT-4 cells and peripheral blood monoc
Synthesis of enzymatically stable analogues of GDP for binding studies with transducin, the G-protein of the visual photoreceptor
Vincent, Stephane,Grenier, Sonya,Valleix, Alain,Salesse, Christian,Lebeau, Luc,Mioskowski, Charles
, p. 7244 - 7257 (2007/10/03)
The synthesis of five enzymatically stable analogues of guanosine diphosphate (GDP) has been carried out. The pyrophosphate moiety was mimicked in turn by the malonate, the acetophosphonate, the phosphonoacetate, the methylene-bis-phosphonate, and the imidodiphosphate groups. All the compounds were prepared via the synthesis of a transient fully protected nucleoside diphosphate analogue, and the final deprotection step was achieved by catalytic hydrogenolysis. The biological properties of the compounds have been evaluated toward transducin, the G-protein of the visual photoreceptor. Three guanosine imidodiphosphate derivatives bearing a linker at different positions on the sugar and on the base were then prepared and evaluated, giving some insight into the GDP binding site of transducin.
N,N-Dibenzyl formamidine as a new protective group for primary amines
Vincent, Stephane,Mons, Stephane,Lebeau, Luc,Mioskowski, Charles
, p. 7527 - 7530 (2007/10/03)
Primary amines can be converted in high yield into N,N-dibenzyl formamidines under mild conditions. The N,N-dibenzyl formamidine group was found to be effective as a protective group for primary amines as it is stable to a variety of conditions and can be removed by catalytic hydrogenation.
