199006-04-7Relevant academic research and scientific papers
Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids
Dragovich, Peter S.,Webber, Stephen E.,Prins, Thomas J.,Zhou, Ru,Marakovits, Joseph T.,Tikhe, Jayashree G.,Fuhrman, Shella A.,Patick, Amy K.,Matthews, David A.,Ford, Clifford E.,Brown, Edward L.,Binford, Susan L.,Meador III, James W.,Ferre, Rose Ann,Worland, Stephen T.
, p. 2189 - 2194 (1999)
Tripeptide-derived molecules incorporating N-methyl amino acid residues and C-terminal Michael acceptor moieties were evaluated as irreversible inhibitors of the cysteine-containing human rhinovirus 3C protease (3CP). Such compounds displayed good 3CP inh
Solid-phase synthesis of irreversible human rhinovirus 3C protease inhibitors. Part 1: Optimization of tripeptides incorporating N-terminal amides
Dragovich, Peter S.,Zhou, Ru,Skalitzky, Donald J.,Fuhrman, Shella A.,Patick, Amy K.,Ford, Clifford E.,Meador III, James W.,Worland, Stephen T.
, p. 589 - 598 (2007/10/03)
The optimization of a series of irreversible human rhinovirus (HRV) 3C protease (3CP) inhibitors is described. These inhibitors are comprised of an l-Leu-l-Phe-l-Gln tripeptide containing an N-terminal amide moiety and a C-terminal ethyl propenoate Michae
