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199006-31-0

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199006-31-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 199006-31-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,9,0,0 and 6 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 199006-31:
(8*1)+(7*9)+(6*9)+(5*0)+(4*0)+(3*6)+(2*3)+(1*1)=150
150 % 10 = 0
So 199006-31-0 is a valid CAS Registry Number.

199006-31-0Downstream Products

199006-31-0Relevant articles and documents

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics

Dragovich, Peter S.,Prins, Thomas J.,Zhou, Ru,Brown, Edward L.,Maldonado, Fausto C.,Fuhrman, Shella A.,Zalman, Leora S.,Tuntland, Tove,Lee, Caroline A.,Patick, Amy K.,Matthews, David A.,Hendrickson, Thomas F.,Kosa, Maha B.,Liu, Bo,Batugo, Minerva R.,Gleeson, Jean-Paul R.,Sakata, Sylvie K.,Chen, Lijian,Guzman, Mark C.,Meador III, James W.,Ferre, Rose Ann,Worland, Stephen T.

, p. 1607 - 1623 (2007/10/03)

The structure-based design, chemical synthesis, and biological evaluation of various 2-pyridone-containing human rhinovirus (HRV) 3C protease (3CP) inhibitors are described. These compounds are comprised of a peptidomimetic binding determinant and a Michael acceptor moiety, which forms an irreversible covalent adduct with the active site cysteine residue of the 3C enzyme. The 2-pyridone-containing inhibitors typically display improved 3CP inhibition properties relative to related peptide-derived molecules along with more favorable antiviral properties. The cocrystal structure of one pyridone-derived 3CP inhibitor complexed with HRV-2 3CP is also described along with certain ab initio conformation analyses. Optimization of the 2-pyridone-containing compounds is shown to provide several highly active 3CP inhibitors (kobs/[I] > 500 000 M-1 s-1) that function as potent antirhinoviral agents (EC50 = 0.05 μM) against multiple virus serotypes in cell culture. One 2-pyridone-containing 3CP inhibitor is shown to be bioavailable in the dog after oral dosing (F = 48%).

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