199010-96-3Relevant academic research and scientific papers
Method for synthesizing 7-methoxyl-1-benzofuran-4-formaldehyde
-
, (2017/05/13)
The invention provides a new method for preparing 7-methoxyl-1-benzofuran-4-formaldehyde. The method comprises the steps of protecting a phenolic hydroxyl group of methoxysalicylaldehyde being a natural product and serving as a raw material with triisopropyl silicon chloride under the alkaline condition; then reacting an aldehyde group with a diazo phosphorus reagent ((1-diazo-2-oxo-propyl)-phosphonic acid dimethyl ester) in a potassium carbonate/methanol solution for converting the aldehyde group into an alkynyl group; performing de-protection of silicon with TBAF (Tetrabutylammonium Fluoride), and then performing ring closing in situ to generate 7-methoxyl-1-benzofuran; and obtaining the 7-methoxyl-1-benzofuran-4-formaldehyde through Vilsmeier aldehyde reaction. Compared with an existing reported preparation method, the preparation method provided by the invention has the advantages of cheap and easily obtained raw materials, less side reaction, high yield and simplicity and convenience in operation, and is beneficial for industrial production.
A New Preparation of Benzofurans Utilizing Trimethylsilyldiazomethane
Ito, Yasuko,Aoyama, Toyohiko,Shioiri, Takayuki
, p. 1163 - 1164 (2007/10/03)
o-Triisopropylsiloxyaryl ketones and aldehydes smoothly reacted with the lithium salt of trimethylsilyldiazomethane to give o-triisopropylsiloxyphenylacetylenes which were easily converted to benzofurans by treatment with tetra-n-butylammonium fluoride. 3-Benzofuranmethanols were also obtained when the reaction was conducted in the presence of carbonyl compounds.
