1991-81-7

Basic information

• Product Name: 4-iodophenylalanine
• Synonyms: 4-Iodophenylalanine; para-Iodophenylalanine; Phenylalanine, 4-iodo-
• CAS NO: 1991-81-7
• Molecular Formula: C₉H₁₀INO₂
• Molecular Weight: 0
• Mol File: 1991-81-7.mol
• Article Data: 32

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-iodophenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-iodophenylalanine(1991-81-7)
• EPA Substance Registry System: 4-iodophenylalanine(1991-81-7)

Safety Data

• Hazardous Substances Data: 1991-81-7(Hazardous Substances Data)

Usage

General Description

4-Iodophenylalanine is a chemical compound that consists of an iodine atom attached to a phenylalanine molecule. This modified amino acid is often used in scientific research and pharmaceutical development due to its potential applications in protein engineering and drug synthesis. The addition of the iodine group imparts unique properties to the phenylalanine molecule, allowing for specific interactions and modifications in biological systems. 4-Iodophenylalanine is commonly utilized as a precursor in the synthesis of radiolabeled proteins and peptides for medical imaging and diagnostic purposes. Additionally, it has been studied for its potential therapeutic effects in the treatment of certain diseases and disorders. Overall, 4-iodophenylalanine is a valuable and versatile chemical with various research and clinical applications.

InChI:InChI=1/C9H10INO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1

Upstream product

• 76410-58-7 p-borono-L-phenylalanine 
• 62040-55-5 p-amino-L-phenylalanine hydrochloride 
• 63-91-2 L-phenylalanine 
• 150-30-1 Phenylalanine 
• 16004-15-2 1-bromomethyl-4-iodobenzene 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 

Downstream Products

• 220400-04-4 N-<(Benzyloxy)carbonyl>-4-iodo-L-phenylalanine 
• 222854-50-4 (L)-4-iodophenylalanine t-butyl ester 
• 210962-68-8 (S)-N-tert-butoxycarbonyl-4-iodophenylalaninol 
• 103882-09-3 N-Boc-4-I-Phe-OH 
• 1173918-59-6 methyl 2-amino-3-(4-iodophenyl)propanoate hydrochloride 
• 1501940-85-7 ((4-methoxyphenyl)((4-(S)-2-(di-tert-butoxycarbonyl)amino)-3-oxo-3-methoxypropyl)phenyl)(trifluoromethanesulfonyl)-λ³-iodane 

Relevant articles and documents

PRODUCTION METHOD FOR RADIOLABELED ARYL COMPOUND

The invention relates to a method of producing the radiolabeled aryl compound (I) Ar—X, or a salt thereof, wherein X is 211At, 210At, 123I, 124I, 125I, or 131I. The method involves reacting the aryl boronic acid compound (II) Ar—Y, or a salt thereof, wherein Y is a borono group (—B(OH)2) or an ester group thereof, with a radionuclide selected from 211At, 210At, 123I, 124I, 125I and 131I, in the presence of an oxidizing agent selected from an alkali metal iodide, an alkali metal bromide, N-bromosuccinimide, N-chlorosuccinimide and hydrogen peroxide, in water.

PENTAFLUOROPHOSPHATE DERIVATIVE, ITS USES AND AN APPROPRIATE MANUFACTURING METHOD

The invention relates to a pentafluorophosphate derivative according to general formula (I): or a pharmaceutically acceptable salt or solvate thereof. Thereby, R1 and R2 denote independently from each other H or F; R3 denotes H, an optionally substituted C1-C10 alkyl, an optionally substituted C3-C10 cycloalkyl, or an optionally substituted C6-C20 aryl, wherein a hydrocarbon chain of the alkyl, the cycloalkyl or the aryl can be interrupted by one or more oxygen, sulfur and/or nitrogen atoms; and M denotes any cation; with the proviso that at least one of R1 and R2 denotes F, if R3 denotes H. The invention further relates to uses of such a pentafluorophosphate derivative and to an appropriate manufacturing method.

Site-Selective Modification of α-Amino Acids and Oligopeptides via Native Amine-Directed γ-C(sp3)-H Arylation

Site-selective modification of chemically and biologically valuable α-amino acids and peptides is of great importance for biochemical study and pharmaceutical development. Few methods based on remote C(sp3)-H functionalization of aliphatic side-chains of peptides has been disclosed in recent years. In this report, we developed a novel approach for γ-C(sp3)-H and γ-/δ-C(sp2)-H arylation of α-amino acids with α-hydrogen by native amine-directed C-H functionalization and further realized the γ-C(sp3)-H arylation of N-terminally unprotected peptides.