199117-78-7

Basic information

• Product Name: 1-(Pyridin-2-yl)piperidin-4-ol
• Synonyms: 4-HYDROXY-1-(PYRIDIN-2-YL)-PIPERIDINE;1-(PYRIDIN-2-YL)PIPERIDIN-4-OL;4-HYDROXY-1-(PYRIDIN-2-YL)-PIPERIDINE >98%;1-(2-Pyridinyl)-4-piperidinol
• CAS NO: 199117-78-7
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.23
• Product Categories: Piperidine
• Mol File: 199117-78-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 340.706 °C at 760 mmHg
• Flash Point: 159.854 °C
• Appearance: /
• Density: 1.173 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: 2-8°C
• PKA: 14.74±0.20(Predicted)
• CAS DataBase Reference: 1-(Pyridin-2-yl)piperidin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Pyridin-2-yl)piperidin-4-ol(199117-78-7)
• EPA Substance Registry System: 1-(Pyridin-2-yl)piperidin-4-ol(199117-78-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 199117-78-7(Hazardous Substances Data)

Usage

Uses

3,4,5,6-Tetrahydro-2H-[1,2'']bipyridinyl-4-ol is a useful reagent for synthesis of indoline derivatives.

InChI:InChI=1/C10H14N2O/c13-9-4-7-12(8-5-9)10-3-1-2-6-11-10/h1-3,6,9,13H,4-5,7-8H2

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 109-09-1 2-chloropyridine 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 264608-40-4 8-(pyridin-2-yl)-1,4-dioxa-8-azaspiro[4.5]decane 
• 264608-41-5 1-(pyridin-2-yl)piperidin-4-one 
• 372-48-5 2-fluoropyridine 
• 109-04-6 2-bromo-pyridine 

Downstream Products

• 1315463-05-8 1-methyl-6-(4-(1-(pyridin-2-yl)piperidin-4-yloxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 
• 199117-85-6 4-<1-(pyridin-2-yl)piperidin-4-yloxy>benzaldehyde 

Relevant articles and documents

INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR TREATING DISEASE

Disclosed herein are dihydroceramide desaturase 1 (Des1) inhibitor compounds and compositions, which are useful in the treatment of diseases, such as metabolic disorders, where inhibition of Des1 is expected to be therapeutic to a patient. Methods of inhibition of Des1 activity in a human or animal subject are also provided.

Azabenzimidazole derivative having AMPK-activating activity

Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen, or substituted or unsubstituted alkyl, R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R1, R2 and R3 are not simultaneously hydrogen, X is a single bond, —S—, —O—, —NR5—, —C(═O)— or the like, R5 is hydrogen, or substituted or unsubstituted alkyl, Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.

1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES

The invention relates to 1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derived Cathepsin S inhibitors of Formula (I), wherein R1 is H or (C1-3)alkyl; R2 is halogen or (C1-4)alkyl, optionally substituted with one or more halogens; n is 1 -3; X is O or CH2; U, V and W are CH; or one of U, V and W is N; Y is a group capable of interacting with the Sn....S2 substites of the active site of Cathepsin S; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.