19914-67-1

Basic information

• Product Name: 13-Ethyl-17-hydroxy-18,19-dinorpregn-5(10)-en-20-yn-3-one
• Synonyms: 13-Ethyl-17-hydroxy-18,19-dinorpregn-5(10)-en-20-yn-3-one;17-Ethinyl-17-hydroxy-18-methylestr-5(10)-en-3-one;13-Ethyl-17a-ethynyl-17-hydroxygon-5(10)-en-3-one;13-Ethyl-17-hydroxy-18,19-dinor-17a-pregn-5(10)-en-20-yn-3-one(Levonorgestrel Impurity B);EP Levonorgestrel Impurity B;13-Ethyl-17-hydroxy-18,19-dinor-17α-pregn-5(10)-en-20-yn-3-one (Levo Norgestrel Impurity);13-ethyl-17-hydroxy-18,19-dinor-17α-pregn-5(10)-en-20-yn-3-one;(17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-5(10)-en-20-yn-3-one
• CAS NO: 19914-67-1
• Molecular Formula: C21H28O2
• Molecular Weight: 312.45
• Product Categories: Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 19914-67-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 169-171?C
• Boiling Point: 454.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• Refractive Index: 1.572
• Storage Temp.: Refrigerator
• PKA: 13.10±0.40(Predicted)
• CAS DataBase Reference: 13-Ethyl-17-hydroxy-18,19-dinorpregn-5(10)-en-20-yn-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 13-Ethyl-17-hydroxy-18,19-dinorpregn-5(10)-en-20-yn-3-one(19914-67-1)
• EPA Substance Registry System: 13-Ethyl-17-hydroxy-18,19-dinorpregn-5(10)-en-20-yn-3-one(19914-67-1)

Safety Data

• Hazardous Substances Data: 19914-67-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

EP Levonorgestrel impurity B

InChI:InChI=1/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,17-19,23H,3,5-13H2,1H3/t17?,18-,19?,20+,21+/m1/s1

Upstream product

• 848-04-4 (+/-)-13-ethyl-3-methoxy-8α-gona-1,3,5(10)-trien-17-one 
• 848-07-7 (+/-)-13-ethyl-3-methoxygona-1,3,5⁽¹⁰⁾,8,14-pentaen-17-one 
• 74-86-2 acetylene 
• 797-63-7 levonorgestrel 

Downstream Products

• 202062-96-2 3,20-bis-ethylenedioxy-13β-ethyl-5α,17α-dihydroxy-11β-{4-[1,1-(ethylenedioxy)ethyl]phenyl}-18,19-dinorpregn-9-ene 
• 202062-90-6 3,20-bis-ethylenedioxy-13β-ethyl-5α,17α-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-18,19-dinorpregn-9-ene 
• 202062-95-1 3,20-bis-ethylenedioxy-13β-ethyl-5α,17α-dihydroxy-11β-[4-(methylthio)phenyl]-18,19-dinorpregn-9-ene 
• 202062-91-7 (8S,11R,13S,14S,17R)-17-Acetyl-11-(4-dimethylamino-phenyl)-13-ethyl-17-hydroxy-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one 
• 202062-97-3 (8S,11R,13S,14S,17R)-17-Acetyl-13-ethyl-17-hydroxy-11-(4-methylsulfanyl-phenyl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one 
• 202062-98-4 13β-ethyl-11β-(4-acetylphenyl)-17α-hydroxy-18,19-dinorpregna-4,9-diene-3,20-dione 

Relevant articles and documents

11β-substituted 13β-ethyl gonane derivatives exhibit reversal of antiprogestational activity

The syntheses of three 17α-acetoxy-13β-ethyl-11β-aryl-18,19- dinorpregna-4,9-diene-3,20 diones from levonorgestrel are described. Despite their close structural similarity to the antiprogesterone CDB-2914, one of the compounds exhibits agonistic progestational activity, and the other two compounds are totally inactive.