199174-29-3

Basic information

• Product Name: (R)-N-Boc-3-(aminomethyl)pyrrolidine
• Synonyms: (R)-3-AMINOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-1-N-BOC-3-(AMINOMETHYL)PYRROLIDINE;(R)-TERT-BUTYL-3-(AMINOMETHYL)PYRROLIDINE-1-CARBOXYLATE;(r)-n-boc-3-(aminomethyl)pyrrolidine;(3R)-3-Aminomethyl-1-Boc-pyrrolidine;REF DUPL: (R)-3-(Aminomethyl)-1-N-Boc-pyrrolidine;(R)-1-Boc-3-(aminomethyl)...;tert-Butyl (3R)-3-(aminomethyl)pyrrolidine-1-carboxylate hydrochloride
• CAS NO: 199174-29-3
• Molecular Formula: C₁₀H₂₀N₂O₂
• Molecular Weight: 200.28
• Product Categories: pharmacetical;Pyrrole&Pyrrolidine&Pyrroline
• Mol File: 199174-29-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 280.3 °C at 760 mmHg
• Flash Point: 123.3 °C
• Appearance: Colorless to yellow/Liquid
• Density: 1.044 g/cm³
• Vapor Pressure: 0.000323mmHg at 25°C
• Refractive Index: 1.4780
• Storage Temp.: 2-8°C
• PKA: 10.12±0.29(Predicted)
• Sensitive: Air Sensitive
• BRN: 10537871
• CAS DataBase Reference: (R)-N-Boc-3-(aminomethyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-Boc-3-(aminomethyl)pyrrolidine(199174-29-3)
• EPA Substance Registry System: (R)-N-Boc-3-(aminomethyl)pyrrolidine(199174-29-3)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• TSCA: No
• Hazardous Substances Data: 199174-29-3(Hazardous Substances Data)

Usage

General Description

(R)-N-Boc-3-(aminomethyl)pyrrolidine is a compound that contains a pyrrolidine ring with a N-Boc-3 substituent. The N-Boc-3 substituent refers to the presence of a tert-butoxycarbonyl (Boc) group at the nitrogen atom in the third position of the pyrrolidine ring. Additionally, the compound has an aminomethyl group attached to the nitrogen atom. (R)-N-Boc-3-(aminomethyl)pyrrolidine is commonly used in organic synthesis and medicinal chemistry as a building block for the creation of pharmaceutical drugs and other chemical compounds. It is often utilized in the preparation of chiral chemicals due to its chiral center, making it an important intermediate in the production of various pharmaceuticals and fine chemicals.

InChI:InChI=1/C10H20N2O2.ClH/c1-10(2,3)14-9(13)12-5-4-8(6-11)7-12;/h8H,4-7,11H2,1-3H3;1H/t8-;/m1./s1

Upstream product

• 7440-02-0 nickel 
• 132945-76-7 tert-butyl (3R)-3-cyano-1-pyrrolidinecarboxylate 
• 132945-78-9 tert-butyl (S)-3-cyanopyrrolidine-1-carboxylate 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 
• 127423-61-4 tert-butyl (3R)-3-methylsulfonyloxypyrrolidine-1-carboxylate 

Downstream Products

• 1394122-84-9 C₁₂H₁₅F₃N₂O₂S*C₂HF₃O₂ 
• 1394122-55-4 N-{[(3S)-1-(4-(3-buten-1-ylamino)-6-{[(2-phenyl-1,3-thiazol-4-yl)methyl]amino}-1,3,5-triazin-2-yl)-3-pyrrolidinyl]methyl}-4-(trifluoromethyl)benzenesulfonamide 
• 1412975-11-1 (1aRS,7bSR)-5-{2-[((R)-1-ethylpyrrolidin-3-ylmethyl)amino]benzene-sulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid 
• 1412978-43-8 tert-butyl (S)-3-[N-benzyl-N-(benzyloxycarbonyl)aminomethyl]pyrrolidine-1-carboxylate 
• 1412978-41-6 benzyl N-((S)-pyrrolidin-3-ylmethyl)-N-benzylcarbamate 

Relevant articles and documents

Novel pyrrolidine or piperidine derivatives having activity for T-type calcium channel

A pyrrolidine or piperidine compound having activity for T - type calcium channel, wherein the pyrrolidine or piperidine compound of Formula 1 according to the present invention has an excellent antagonistic activity to, T-type calcium channel, and can be used as a preventive or therapeutic agent, for pain diseases, or cancer related to cancer, or cancer such as, epilepsy and,hepatic pain, angina. (by machine translation)

CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY

The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

Antithrombotic agents

Compounds of formula (I) : are antithrombotic agents, having utility in a variety of therapeutic areas including the prevention and/or treatment of deep vein thrombosis (DVT) after surgery, major medical illness, paralysis, malignancy, prolonged immobilis