199192-13-7

Upstream product

• 131134-65-1 2-(1-Allyl-3-methyl-but-2-enyl)-2-methyl-[1,3]dioxolane 
• 58143-80-9 3-allyl-5-methyl-hex-4-en-2-one 
• 1072-82-8 3-acetylpyrrole 
• 107-10-8 propylamine 
• 131134-69-5 2-(2-Methyl-[1,3]dioxolan-2-yl)-succinaldehyde 

Relevant academic research and scientific papers

Bu3SnH mediated oxidative radical cyclisation onto imidazoles and pyrroles

A new protocol using radical cyclisation has been developed for the synthesis of [1,2-c]-fused imidazoles and [1,2-a]-fused pyrroles. The intermediate nucleophilic N-alkyl radicals, generated using Bu3SnH from N- (ω-bromoalkyl) or N-[ω-(phenylselanyl)alkyl] imidazoles and pyrroles, undergo regio-selective radical cyclisalion onto the azole rings followed by oxidative re-aromatisation.

Oxidative radical cyclisations onto imidazoles and pyrroles using Bu3SnH

Oxidative radical cyclisation using Bu3SnH has been used for the synthesis of [1,2-c]-fused imidazoles and [1,2-a]-fused pyrroles from imidazolecarbaldehydes and acylpyrroles respectively. The intermediate nucleophilic N-alkyl radicals cyclise onto imidazole and pyrrole rings followed by oxidative re-aromatisation.

SYNTHESE D'ACETOACETALDEHYDES MONO- ET DI-SUBSTITUES PAR DES CHAINES FONCTIONNALISEES

These synthons, which are useful in the synthesis of indole alkaloids, were prepared through alkylation of enone 4 and further ozonolysis, after eventual protection in the form of dioxolane derivatives.