1992-01-4

Basic information

• Product Name: 2-(4-aMino-3-Methoxyphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
• Synonyms: 2-(4-aMino-3-Methoxyphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
• CAS NO: 1992-01-4
• Molecular Formula: C₁₀H₉F₆NO₂
• Molecular Weight: 289.1743792
• Mol File: 1992-01-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-aMino-3-Methoxyphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-aMino-3-Methoxyphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol(1992-01-4)
• EPA Substance Registry System: 2-(4-aMino-3-Methoxyphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol(1992-01-4)

Safety Data

• Hazardous Substances Data: 1992-01-4(Hazardous Substances Data)

Usage

Hexafluorinated derivative

Propan-2-ol The compound is derived from propan-2-ol and has six fluorine atoms replacing six hydrogen atoms, giving it unique properties.

Amino and methoxy groups

Phenyl ring The compound contains both an amino (-NH2) and a methoxy (-OCH3) group attached to the phenyl ring, which contributes to its reactivity and versatility in chemical reactions.

Building block

Synthesis of pharmaceuticals, agrochemicals, and materials science applications The compound is used as a starting material or intermediate in the production of various chemicals and materials, making it valuable in multiple industries.

Unique chemical structure

The specific arrangement of functional groups and the hexafluorinated nature of the compound make it an important intermediate in the production of fine chemicals and advanced materials.

Enhanced stability and resistance to degradation

The presence of six fluorine atoms in the compound grants it increased stability and resistance to degradation, making it particularly useful in industries that require high-performance and long-lasting products.

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 684-16-2 Hexafluoroacetone 

Downstream Products

• 71260-02-1 N-{2-methoxy-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-3-oxo-butanamide 

Relevant articles and documents

Novel Nonsteroidal Progesterone Receptor (PR) Antagonists with a Phenanthridinone Skeleton

The progesterone receptor (PR) plays an important role in various physiological systems, including female reproduction and the central nervous system, and PR antagonists are thought to be effective not only as contraceptive agents and abortifacients but also in the treatment of various diseases, including hormone-dependent cancers and endometriosis. Here, we identified phenanthridin-6(5H)-one derivatives as a new class of PR antagonists and investigated their structure-activity relationships. Among the synthesized compounds, 37, 40, and 46 exhibited very potent PR antagonistic activity with high selectivity for PR over other nuclear receptors. These compounds are structurally distinct from other nonsteroidal PR antagonists, including cyanoaryl derivatives, and should be useful for further studies of the clinical utility of PR antagonists.

Liver X receptor (LXR) modulators with dibenz[b,f]-[1,4]oxazepin-11-one, (Z)-dibenz[b,f]azocin-6-one, and 11,12-dihydrodibenz[b,f]azocin-6-one skeletons

Conformationally restricted heterocyclic analogs of carba-T0901317 with dibenz[b,f][1,4]oxazepin-11-one, 11,12-dihydrodibenz[b,f)azocin-6-one, and (Z)-dibenz[b,f]-azocin-6-one skeletons were prepared as candidate for liver X receptor (LXR) agonists. In vitro transactivation assay revealed that the activity depends on the nature of the linking group.

Antihypertensive polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils

Polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils, such as 2,3-dihydro-7-methyl-9-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-5H-pyrido[1,2,3-de]-1,4-benzoxazin-5-one, useful as antihypertensive agents.