1992-09-2

Basic information

• Product Name: 2-(4-AMINO-3-METHYLPHENYL)HEXAFLUOROISOPROPANOL
• Synonyms: 2-(4-AMINO-3-METHYLPHENYL)HEXAFLUOROISOPROPANOL;2-(4-AMINO-3-METHYLPHENYL)HEXAFLUOROISOPROPANOL, 97% MIN.;2-(4-Amino-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol;4-(1,1,1,3,3,3-Hexafluoro-2-hydroxyprop-2-yl)-2-methylaniline, 2-Amino-5-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)toluene
• CAS NO: 1992-09-2
• Molecular Formula: C₁₀H₉F₆NO
• Molecular Weight: 273.17
• Mol File: 1992-09-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 135-136 °C
• Boiling Point: Safety Data
  1. N/A
  2. N/A
  3. N/A
  6. N/A
  7. N/A
  8. 1992-09-2(Hazardous Substances Data)
• Hazardous Substances Data: 1992-09-2(Hazardous Substances Data)

Usage

General Description

2-(4-AMINO-3-METHYLPHENYL)HEXAFLUOROISOPROPANOL, also known as Hexafluoroisopropanol, is a chemical compound with the molecular formula C9H12F6NO. It is a colorless liquid with a strong odor and is commonly used as a solvent in organic synthesis and in the pharmaceutical industry. Hexafluoroisopropanol is known for its strong acidity and is used as a catalyst in various chemical reactions. It is also used as an additive in electrolytes for lithium ion batteries and as a solvent for polymers and resins. The compound is known for its low toxicity and environmental impact, making it a widely used chemical in various industries.

InChI:InChI=1/C10H9F6NO/c1-5-4-6(2-3-7(5)17)8(18,9(11,12)13)10(14,15)16/h2-4,18H,17H2,1H3

Upstream product

• 95-53-4 o-toluidine 
• 920-66-1 1,1,1,3',3',3'-hexafluoro-propanol 
• 684-16-2 Hexafluoroacetone 

Relevant articles and documents

Design, synthesis and insecticidal activity of novel analogues of flubendiamide containing alkoxyhexafluoroisopropyl groups

Flubendiamide has received considerable attention in the agriculture field due to its novel mode of action and excellent insecticidal activity. However, the high cost and toxicity to aquatic invertebrates associated with flubendiamide limit its agronomic utility. On the basis of the structure of the lead compound, flubendiamide, we designed and synthesized a series of novel analogues of flubendiamide bearing a alkoxyhexafluoroisopropyl moiety using 2-methyl-4-(2-alkoxyhexafluoroisopropyl) anilines as the key intermediates. Their insecticidal activities against the oriental armyworm (Mythimna separataWalker) were evaluated. The results indicated that most of the target compounds exhibited high insecticidal activities. Specifically, compound8hshowed the best insecticidal activity against the armyworm and its insecticidal activity reached 70% at 0.156 mg L?1. The LC50value of compound8h(0.0512 mg L?1) is nearly the same as the corresponding commercial product flubendiamide (0.0412 mg L?1). Furthermore, the acute toxicity test showed that the 48 h LC50values of compound8hand flubendiamide againstDaphnia magnaStraus were 0.0066 and 0.0021 mg L?1, respectively. The toxicity of compound8his obviously lower than flubendiamide.

Cobalt-Catalyzed Selective Functionalization of Aniline Derivatives with Hexafluoroisopropanol

A cobalt-catalyzed site-selective functionalization of aniline derivatives with hexafluoroisopropanol, which enables the synthesis of a wide array of fluoroalkylated anilines, a class of highly valuable building blocks for further preparation of fluorinated functional products, is reported. The developed transformation proceeds with operational simplicity, use of earth-abundant metal catalyst, broad substrate scope, good functional group tolerance, and mild reaction conditions.

Modulators of the nuclear hormone receptor ROR

The invention provides small molecule modulators of retinoic acid receptor-related orphan receptors such as RORα, RORβ, or RORγ, of formula with the variable atoms as defined herein and R1 comprising a hydroxyl- or alkoxyl-substituted fluoroalkyl group. Compounds of the invention can be effective modulators at concentrations ineffective to act on LXR receptors, or on other nuclear receptors, or other biological targets. Methods of modulation the RORs and methods of treating metabolic disorders, immune disorders, cancer, and CNS disorders wherein modulation of an ROR is medically indicated are also provided.