1992-30-9

Upstream product

• 95-51-2 o-chloroaniline 
• 684-16-2 Hexafluoroacetone 

Downstream Products

• 1355338-10-1 N⁽²⁾-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N⁽¹⁾-[4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-2-chlorophenyl]-1,2-benzenedicarboxamide 
• 872690-68-1 N-[2-chloro-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-acetamide 

Relevant academic research and scientific papers

Efficient lead finding, activity enhancement and preliminary selectivity control of nuclear receptor ligands bearing a phenanthridinone skeleton

Background: Nuclear receptors (NRs) are considered as potential drug targets because they control diverse biological functions. However, steroidal ligands for NRs have the potential to cross-react with other nuclear receptors, so development of non-steroi

Synthesis and insecticidal activities of novel analogues of flubendiamide containing a hexafluoroisopropanol moiety

Ten novel analogues of flubendiamide containing a hexafluoroisopropanol moiety were designed and synthesized. Their insecticidal activities against armyworm (Pseudaletia separata Walker) were examined and compared with the commercial product flubendiamide. Compound 7b showed nearly the same insecticidal activity as flubendiamide against armyworm.

Novel hexafluoroisopropanol derivatives

The invention is concerned with novel hexafluoroisopropanol derivatives of formula (I) wherein R1 to R6, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. The

FUSED-RING PYRIMIDIN-4(3H)-ONE DERIVATIVES, PROCESSES FOR THE PREPARATION AND USES THEREOF

AbstractNovel compounds of the following formula (I) and pharmacologically acceptable salt and esters thereof can modulate LXR function and as a result show excellent anti-arteriosclerotic and anti-inflammatory activity:wherein:A represents aryl or heteroaryl;R1, R2 and R3 are the same or different and each represents hydrogen, hydroxyl, nitro, cyano, amino, halogen, carboxy, carbamoyl, mercapto, alkyl, haloalkyl, alkylcarbonyloxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino, alkylcarbonylamino, N-(alkylcarbonyl)-N-(alkyl)amino, alkoxycarbonylamino, N-(alkoxycarbonyl)-N-(alkyl)amino, alkylsulfonylamino, N-(alkylsulfonyl)-N-(alkyl)amino, haloalkylsulfonylamino, N-(haloalkylsulfonyl)-N-(alkyl)amino, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group, or R1 and R2 together are alkylenedioxy;R4 and R5 are the same or different and each represents hydrogen, hydroxyl, amino, halogen, mercapto, alkyl, haloalkyl, alkoxy, alkoxycarbonyl or alkylthio;X represents hydrogen, hydroxyl, halogen, alkoxy or haloalkoxy; andY represents an optionally substituted alkyl, cycloalkyl, heterocyclyl, aryl, cycloalkylalkyl, heterocyclylalkyl or aralkyl group.

REACTIONS OF HIGHLY ELECTROPHILIC POLYFLUOROCARBONYL COMPOUNDS WITH PRIMARY ARYLAMINES

C-Hydroxyalkylation of primary arylamines by highly electrophilic polyfluorocarbonyl compounds results from the direct reaction of the initial reagents and is competitively inhibited by equilibrium N-hydroxyalkylation.The presence of steric hindrances to