199277-80-0

Usage

Uses

Used in Pharmaceutical Industry:
(S)-2-[4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-6-methylpyridine is used as a synthetic intermediate for the development of new pharmaceutical compounds. Its unique structure allows it to be a key component in the creation of drugs targeting specific biological pathways or receptors, potentially leading to novel treatments for various diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical sector, (S)-2-[4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-6-methylpyridine is utilized as a precursor in the synthesis of new agrochemicals. Its incorporation into these products can enhance the effectiveness of pesticides, herbicides, or other agricultural chemicals, contributing to more efficient and targeted crop protection.
Used in Material Science:
(S)-2-[4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-6-methylpyridine also finds application in material science, where it can be employed to develop new materials with specific properties. Its use in this field may lead to advancements in areas such as polymer science, where it could contribute to the creation of materials with improved strength, flexibility, or other desirable characteristics.
It is crucial to handle (S)-2-[4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-6-methylpyridine with care due to its potential chemical hazards and the need for specialized handling procedures to ensure safety and effectiveness in its applications.

InChI:InChI=1/C13H18N2O/c1-9-6-5-7-10(14-9)12-15-11(8-16-12)13(2,3)4/h5-7,11H,8H2,1-4H3/t11-/m1/s1

Upstream product

• 1620-75-3 2-Cyano-6-methylpyridine 
• 20859-02-3 L-tert-Leucine 
• 129821-92-7 methyl 6-methylpicolinimidate 
• 112245-13-3 (S)-tert-leucinol 

Downstream Products

• 2570984-82-4 (S)-2-(6-benzhydrylpyridin-2-yl)-4-(tert-butyl)-4,5-dihydrooxazole 
• 1800190-39-9 (S)-2-(6-benzylpyridin-2-yl)-4-(tert-butyl)-4,5-dihydrooxazole 

Relevant academic research and scientific papers

Cobalt-Catalyzed Asymmetric Hydrogenation of Vinylsilanes with a Phosphine-Pyridine-Oxazoline Ligand: Synthesis of Optically Active Organosilanes and Silacycles

The asymmetric hydrogenation of vinylsilanes catalyzed by a new C1-symmetric phosphine-pyridine-oxazoline cobalt complex is described. The method provides an efficient approach to chiral tertiary silanes with enantioselectivities up to 99% ee.

Phosphine pyridine oxazoline compound, metal complex, and preparation method and application thereof

The invention discloses a phosphine pyridine oxazoline compound, a metal complex, and a preparation method and application thereof. According to the invention, the preparation methods of the phosphinepyridine oxazoline compound and the metal complex are s

Enantioselective Synthesis of N-Benzylic Heterocycles: A Nickel and Photoredox Dual Catalysis Approach

Reported herein is a dual nickel- and photoredox-catalyzed modular approach for the preparation of enantioenriched N-benzylic heterocycles. α-Heterocyclic carboxylic acids, easily obtainable from common commercial material, are reported as suitable substrates for a decarboxylative strategy in conjunction with a chiral pyridine-oxazoline (PyOx) ligand, providing quick access to enantioenriched drug-like products. The presence of a directing group on the heterocyclic moiety is shown to be beneficial, affording improved stereoselectivity in a number of cases.

Chemoselective oxidation of polyols with chiral palladium catalysts

Chiral palladium-based catalysts derived from pyridinyl oxazoline (pyOx) ligands catalyze the oxidation of alcohols, including 1,2-diols, triols, and tetraols, with high regio- and chemoselectivity. Screening of various chiral oxazoline-derived ligands for the oxidation of a model diol, 1,2-propanediol (1,2-PD), revealed that the nature of the ligand had a significant influence on the activity and chemoselectivity for oxidation of vicinal diols. The PyOx ligands containing an α-methyl substituent were the most active for the oxidation of 1,2-PD using benzoquinone as the terminal oxidant. Oxidation of vicinal diols and polyols occurs selectively at the secondary alcohol to afford α-hydroxy ketones in isolated yields of 62-87%. Chemoselective oxidation of meso-erythritol with the chiral [(S)-(α-Me(tert-Bu)PyOx)Pd(OAc)] 2[OTf]2 afforded (S)-erthyrulose in 62% yield and 24% ee.

Chiral oxazolinylpyridines as ligands for enantioselective palladium catalysed allylic substitution

Chiral oxazolinylpyridines were prepared and assessed in the enantioselective palladium catalysed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethyl malonate. Enantioselectivity up to 91% was obtained.