199277-80-0

Basic information

• Product Name: (S)-2-[4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-6-methylpyridine
• Synonyms: (S)-2-[4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-6-methylpyridine;2-[(4S)-4-(tert-Butyl)-4,5-dihydro-2-oxazolyl]-6-methylpyridine;(S)-4-(tert-Butyl)-2-(6-methylpyridin-2-yl)-4,5-dihydrooxazole
• CAS NO: 199277-80-0
• Molecular Formula: C13H18N2O
• Molecular Weight: 218.29
• Product Categories: Chiral Reagents
• Mol File: 199277-80-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 328.755 °C at 760 mmHg
• Flash Point: 152.626 °C
• Appearance: /
• Density: 1.07
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.83±0.19(Predicted)
• CAS DataBase Reference: (S)-2-[4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-6-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-6-methylpyridine(199277-80-0)
• EPA Substance Registry System: (S)-2-[4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-6-methylpyridine(199277-80-0)

Safety Data

• Hazardous Substances Data: 199277-80-0(Hazardous Substances Data)

Usage

General Description

(S)-2-[4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-6-methylpyridine is a chemical compound with a complex structure, consisting of a pyridine ring with a methyl and a 2-oxazolyl group attached. The 2-oxazolyl group contains a 1,1-dimethylethyl substituent. (S)-2-[4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-6-methylpyridine is often used as a building block for the synthesis of larger organic molecules, and it may have potential applications in pharmaceuticals, agrochemicals, or material science. It is important to handle and use this compound with caution, as it may have specific chemical hazards or require specialized handling procedures.

InChI:InChI=1/C13H18N2O/c1-9-6-5-7-10(14-9)12-15-11(8-16-12)13(2,3)4/h5-7,11H,8H2,1-4H3/t11-/m1/s1

Upstream product

• 1620-75-3 2-Cyano-6-methylpyridine 
• 112245-13-3 (S)-tert-leucinol 
• 20859-02-3 L-tert-Leucine 
• 129821-92-7 methyl 6-methylpicolinimidate 

Downstream Products

• 2570984-82-4 (S)-2-(6-benzhydrylpyridin-2-yl)-4-(tert-butyl)-4,5-dihydrooxazole 
• 1800190-39-9 (S)-2-(6-benzylpyridin-2-yl)-4-(tert-butyl)-4,5-dihydrooxazole 

Relevant articles and documents

Cobalt-Catalyzed Asymmetric Hydrogenation of Vinylsilanes with a Phosphine-Pyridine-Oxazoline Ligand: Synthesis of Optically Active Organosilanes and Silacycles

The asymmetric hydrogenation of vinylsilanes catalyzed by a new C1-symmetric phosphine-pyridine-oxazoline cobalt complex is described. The method provides an efficient approach to chiral tertiary silanes with enantioselectivities up to 99% ee.

Enantioselective Synthesis of N-Benzylic Heterocycles: A Nickel and Photoredox Dual Catalysis Approach

Reported herein is a dual nickel- and photoredox-catalyzed modular approach for the preparation of enantioenriched N-benzylic heterocycles. α-Heterocyclic carboxylic acids, easily obtainable from common commercial material, are reported as suitable substrates for a decarboxylative strategy in conjunction with a chiral pyridine-oxazoline (PyOx) ligand, providing quick access to enantioenriched drug-like products. The presence of a directing group on the heterocyclic moiety is shown to be beneficial, affording improved stereoselectivity in a number of cases.

Chiral oxazolinylpyridines as ligands for enantioselective palladium catalysed allylic substitution

Chiral oxazolinylpyridines were prepared and assessed in the enantioselective palladium catalysed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethyl malonate. Enantioselectivity up to 91% was obtained.