199277-87-7Relevant academic research and scientific papers
Efficient constructions of the four different thienopyrimidinone skeletons via various cyclocondensation of o-aminothienonitrile with carbonyl compounds
Yang, Junjuan,Shi, Daxin,Zhang, Kai,Zhao, Zhangtao,Qiu, Fadong,Bi, Yujiao,Zhang, Qi,Li, Jiarong
, p. 866 - 885 (2016)
A series of new thienopyrimidinone derivatives were synthesized via a novel, straightforward and efficient tandem cyclocondensation of o-aminothienonitrile 1 and carbonyl compounds 2 in different conditions. The synthesized four thienopyrimidinone skeleto
Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors
Sleebs, Brad E.,Nikolakopoulos, George,Street, Ian P.,Falk, Hendrik,Baell, Jonathan B.
, p. 5992 - 5994 (2011/10/18)
4-Aminobenzothieno[3,2-d]pyrimidines were previously identified in a high throughput screening campaign as LIMK1 inhibitors. Scaffold reversal led to the identification of a series of simple 5,6-substituted 4-aminothieno[2,3-d] pyrimidines with low micromolar inhibition of LIMK1.
