199291-07-1

Basic information

• Product Name: 2-[1-(Toluene-4-sulfonyl)-1H-pyrrol-2-yl]-propionaldehyde
• Synonyms: 2-[1-(Toluene-4-sulfonyl)-1H-pyrrol-2-yl]-propionaldehyde
• CAS NO: 199291-07-1
• Molecular Weight: 277.344
• Mol File: 199291-07-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[1-(Toluene-4-sulfonyl)-1H-pyrrol-2-yl]-propionaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(Toluene-4-sulfonyl)-1H-pyrrol-2-yl]-propionaldehyde(199291-07-1)
• EPA Substance Registry System: 2-[1-(Toluene-4-sulfonyl)-1H-pyrrol-2-yl]-propionaldehyde(199291-07-1)

Safety Data

• Hazardous Substances Data: 199291-07-1(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 102619-05-6 1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde 
• 1003-29-8 2-pyrrole aldehyde 
• 201230-82-2 carbon monoxide 
• 131124-21-5 1-(toluene-4-sulfonyl)-2-vinyl-1H-pyrrole 

Relevant articles and documents

Influence of the reaction temperature on the regioselectivity in the rhodium-catalyzed hydroformylation of vinylpyrroles

The influence of the temperature on the regioselectivity in the hydroformylation of the vinylpyrrole isomers and of the corresponding N-tosylated substrates has been investigated in the range 20-100°C, in the presence of Rh4(CO)12. At all the temperatures the branched aldehyde was prevailing with respect to the linear isomer for all the substrates ( α-regioselectivity). With increasing temperature, an increase of the linear aldehyde was observed to a different extent in dependence on the substrate nature. 2H NMR investigation of the crude reaction mixture recovered from deuterioformylation of 3-vinylpyrrole at partial substrate conversion points out that the observed depression of the α-regioselectivity with increasing temperature must be connected to a β-hydride elimination process occurring for the branched alkyl-rhodium intermediates but not for the linear ones.