199296-20-3Relevant academic research and scientific papers
Novel pyrazinone inhibitors of mast cell tryptase: Synthesis and SAR evaluation
Hopkins, Corey,Neuenschwander, Kent,Scotese, Anthony,Jackson, Sharon,Nieduzak, Thaddeus,Pauls, Henry,Liang, Guyan,Sides, Keith,Cramer, Dona,Cairns, Jennifer,Maignan, Sebastien,Mathieu, Magali
, p. 4819 - 4823 (2007/10/03)
In this manuscript, the synthesis and SAR evaluation of a novel pyrazinone class of tryptase inhibitors is described. Chemical optimization of the P1 and P4 groups led to the identification of 7p (Ki = 93 nM) as a potent inhibitor of mast cell tryptase.
Non-peptide αvβ3 antagonists. Part 6: Design and synthesis of αvβ3 antagonists containing a pyridone or pyrazinone central scaffold
Breslin, Michael J.,Duggan, Mark E.,Halczenko, Wasyl,Fernandez-Metzler, Carmen,Hunt, Cecilia A.,Leu, Chih-Tai,Merkle, Kara M.,Naylor-Olsen, Adel M.,Prueksaritanont, Thomayant,Stump, Gary,Wallace, Audrey,Rodan, Sevgi B.,Hutchinson, John H.
, p. 1809 - 1812 (2007/10/03)
Two novel series of small-molecule RGD mimetics containing either a substituted pyridone or pyrazinone central constraint were prepared. Modification of the β-alanine 3-substituent produced compounds that are potent and selective αvβ3 antagonists and exhibit a range of physicochemical properties.
PYRAZINONE THROMBIN INHIBITORS
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, (2008/06/13)
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: STR1 for example: STR2
