199383-85-2Relevant academic research and scientific papers
Desymmetrisation of prochiral ketones by catalytic enantioselective hydrolysis of their enol esters using enzymes
Carnell, Andrew J.,Barkley, Jim,Singh, Amarjit
, p. 7781 - 7784 (1997)
Desymmetrisation of 4-cyano-4-phenylcyclohexanone 1 has been achieved by enzyme-catalysed enantioselective alcoholysis with n-butanol of the derived racemic enol acetate 2 in tetrahydrofuran. The absolute configuration of the enol aceate (-)-(S)-2 (100% e.e.) obtained was determined by X-ray analysis of the camphanyl derivative 7.
