199390-80-2

Upstream product

• 37620-37-4 (E)-4-chloro-4'-methylchalcone 
• 109-77-3 malononitrile 
• 13565-39-4 3-(4-chlorophenyl)-1-p-tolylprop-2-en-1-one 

Downstream Products

• 94360-35-7 2-Bromo-4-(4-chloro-phenyl)-6-p-tolyl-nicotinonitrile 
• 94360-45-9 4-(4-Chloro-phenyl)-2-morpholin-4-yl-6-p-tolyl-nicotinonitrile 
• 94360-39-1 2-Benzyloxy-4-(4-chloro-phenyl)-6-p-tolyl-nicotinonitrile 
• 94360-42-6 4'-(4-Chloro-phenyl)-6'-p-tolyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile 

Relevant academic research and scientific papers

A convenient synthesis of (3-oxo-1,3-diaryl) propylpropanedinitrile catalyzed by KF-alumina

A series of (3-oxo-1,3-diaryl) propylpropanedinitriles were synthesized by Michael addition reaction of chalcones and malononitriles in the presence of potassium fluoride on alumina.

Cu(II)-Promoted Cascade Synthesis of Fused Imidazo-Pyridine-Carbonitriles

A Cu(II)-promoted synthesis of an aza-fused N-heterocycle having a benz-imidazopyridine scaffold is developed via an addition-cyclization reaction followed by an Ullmann-type C-N coupling between o-iodoanilines and γ-ketodinitriles. This protocol features a broad substrate scope, giving products in 32-84% yields. The compounds show excellent photoluminescence properties having two absorption maxima in the region between 270-280 and 338-350 nm and emission maxima in the range of 502-533 nm. The HOMO-LUMO energy gap of 3.49-3.57 eV was determined using Gaussian 09 at the B3LYP/6-31G (d, p) basis set level. We also demonstrated a few postsynthetic modifications.

Visible-light-accelerated pd-catalyzed cascade addition/ cyclization of arylboronic acids to γ- And β-ketodinitriles for the construction of 3-cyanopyridines and 3-cyanopyrrole analogues

The one-pot synthetic strategies for 2,4,6-triarylnicotinonitriles and 2,5-diaryl-1H-pyrrole-3-carbonitriles have been accomplished via a Pd-catalyzed coupling of arylboronic acid with 2-(3-oxo-1,3-diarylpropyl)malononitrile and 2-(2-oxo-2- arylethyl)malo

Immobilization of lipase on Fe3O4/ZnO core/shell magnetic nanoparticles and catalysis of Michael-type addition to chalcone derivatives

Fe3O4/ZnO core/shell magnetic nanoparticles in 1:1 and 1:2 molar ratios were prepared and characterized by using X-ray powder diffraction, scanning electron microscopy, thermogravimetric analysis, FT-IR spectra, and flame atomic abso