199391-75-8

Basic information

• Product Name: 2,3-bis(2-hydroxyethyl)phenol
• CAS NO: 199391-75-8
• Molecular Formula: C₁₀H₁₄O₃
• Molecular Weight: 182.2164
• Mol File: 199391-75-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 367.5°C at 760 mmHg
• Flash Point: 183°C
• Density: 1.226g/cm³
• Vapor Pressure: 4.75E-06mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 2,3-bis(2-hydroxyethyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-bis(2-hydroxyethyl)phenol(199391-75-8)
• EPA Substance Registry System: 2,3-bis(2-hydroxyethyl)phenol(199391-75-8)

Safety Data

• Hazardous Substances Data: 199391-75-8(Hazardous Substances Data)

Usage

General Description

2,3-bis(2-hydroxyethyl)phenol, also known as bisphenol F, is a chemical compound that belongs to the family of bisphenols. It is commonly used in the production of epoxy resins, which are widely used in the manufacturing of plastics, adhesives, and coatings. Bisphenol F is also utilized in the production of flame retardants, as well as in the synthesis of pharmaceuticals and other organic compounds. It is known for its high thermal stability and resistance to chemicals, making it a popular choice for various industrial applications. However, there is ongoing research and concern over its potential health and environmental impacts, particularly its potential for endocrine disruption and its persistence in the environment.

Upstream product

• 36192-01-5 5,8-dihydro-1-naphthyl benzyl ether 
• 27673-48-9 5,8-dihydro-1-naphthol 
• 90-15-3 α-naphthol 

Downstream Products

• 230642-83-8 C₁₇H₁₈O₄S 

Relevant articles and documents

Tasimelteon intermediate and preparation method thereof

The invention provides a tasimelteon intermediate and a preparation method thereof. The preparation method comprises the following steps: with a compound a as a raw material, reacting the compound a with benzyl bromide so as to obtain a compound I; then subjecting the compound I to a reaction under the action of a combined catalyst consisting of potassium osmate dihydrate, potassium carbonate, potassium ferricyanide, benzyltriethylammonium chloride and methane sulfonamide or a combined catalyst consisting of osmium tetroxide, potassium carbonate, potassium ferricyanide, benzyltriethylammonium chloride and methane sulfonamide so as to obtain a compound II; subjecting the compound II to an oxidation reaction under the action of sodium periodate or lead tetraacetate so as to obtain an intermediate compound III and carrying out a reduction reaction so as to obtain a compound IV; and subjecting the compound IV to a reduction reaction to remove a benzyl protective group so as to obtain a compound V, then reacting the compound V with p-toluene sulfonyl chloride, carrying out hydroxyl protection and then carrying out cyclization under the action of potassium carbonate so as to obtain the tasimelteon intermediate compound VI. The invention provides a novel process for preparation of the tasimelteon intermediate; and the prepared tasimelteon intermediate has good purity and high quality and is applicable to industrial production.

ACYL GUANIDINE SODIUM/PROTON EXCHANGE INHIBITORS AND METHOD

Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C-R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; and R1, R2, R3 and R4 are as defined herein, and where X is N, R1 is preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above acyl guanidines.