1994-13-4

Basic information

• Product Name: 6-FLUORO-4-HYDROXYCOUMARIN
• Synonyms: 6-FLUORO-4-HYDROXY-2H-CHROMEN-2-ONE;6-FLUORO-4-HYDROXYCOUMARIN;6-Fluoro-4-hydroxycoumarine;2H-1-Benzopyran-2-one, 6-fluoro-4-hydroxy-
• CAS NO: 1994-13-4
• Molecular Formula: C₉H₅FO₃
• Molecular Weight: 180.13
• Product Categories: API intermediates;Building Blocks;Coumarins;Heterocyclic Building Blocks
• Mol File: 1994-13-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: 248-251 °C(lit.)
• Boiling Point: 292.1°C at 760 mmHg
• Flash Point: 130.5°C
• Appearance: /
• Density: 1.549g/cm³
• Vapor Pressure: 0.000854mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 4.50±1.00(Predicted)
• CAS DataBase Reference: 6-FLUORO-4-HYDROXYCOUMARIN(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-4-HYDROXYCOUMARIN(1994-13-4)
• EPA Substance Registry System: 6-FLUORO-4-HYDROXYCOUMARIN(1994-13-4)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• Hazardous Substances Data: 1994-13-4(Hazardous Substances Data)

Usage

General Description

6-FLUORO-4-HYDROXYCOUMARIN, also known as 6-Fluoro-4-Coumarinol, is an organic compound that belongs to the coumarin family. It is a fluorescent derivative of coumarin and is commonly used in fluorescence assays and biological imaging. This chemical is known for its ability to produce a green fluorescence when exposed to ultraviolet light. It has also been studied for its potential therapeutic applications, including its anticancer and anti-inflammatory properties. Additionally, 6-FLUORO-4-HYDROXYCOUMARIN has been used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Overall, this chemical compound has demonstrated diverse applications in research and industry.

InChI:InChI=1/C9H5FO3/c10-5-1-2-8-6(3-5)7(11)4-9(12)13-8/h1-4,12H

Upstream product

• 371-41-5 4-Fluorophenol 
• 141-82-2 malonic acid 
• 1994-31-6 2-(4-fluorophenoxy)carbonyl acetic acid 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 105-58-8 Diethyl carbonate 
• 1810-25-9 bis(4-fluorophenyl) malonate 

Downstream Products

• 942120-90-3 3-bromo-6-fluoro-4-tosyloxycoumarin 
• 1152668-99-9 C₁₅H₈ClFO₂ 
• 1338247-94-1 6-fluoro3-(2-hydroxybenzylidene)chroman-2,4-dione 
• 1338247-95-2 6-fluoro-3-(2-hydroxy-3-methoxybenzylidene)chroman-2,4-dione 
• 1426835-16-6 6-fluoro-3-((1-(4-fluorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)(4-methoxyphenyl)methyl)chroman-2,4-dione 
• 1426835-15-5 6-fluoro-3-((4-hydroxy-3-methoxyphenyl)(3-methyl-5-oxo-1-p-tolyl-4,5-dihydro-1H-pyrazol-4-yl)-methyl)chroman-2,4-dione 
• 1426835-10-0 6-fluoro-3-((4-hydroxy-3-methoxyphenyl)(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)methyl)chroman-2,4-dione 
• 1449795-46-3 C₂₃H₁₄FNO₂ 
• 1537195-73-5 4-((6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(6-fluoro-4-hydroxy-2-oxo-2H-chromen-3-yl)methyl)benzonitrile 
• 1537195-77-9 6-amino-5-((1,3-diphenyl-1H-pyrazol-4-yl)(6-fluoro-4-hydroxy-2-oxo-2H-chromen-3-yl)methyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 
• 1537195-78-0 6-amino-5-((6-fluoro-4-hydroxy-2-oxo-2H-chromen-3-yl)(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

Copper(II)-Catalyzed Tandem Reaction: Synthesis of Furo[3,2- c]coumarin Derivatives and Evaluation for Photophysical Properties

An efficient protocol for synthesizing furo[3,2-c]coumarin derivatives is described. The novel reaction could afford the desired furocoumarins with good to excellent yields in a mild and rapid manner. Large substrate scope screening and scale-up preparation have also been accomplished, and selected compounds were evaluated for their photophysical properties.

Regioselective Synthesis of 4,5-Dihydro-6H-oxepino[3,2-c]chromene-2,6(3H)-diones through Palladium-Catalyzed Intramolecular Alkoxycarbonylation of 3-Allyl-4-hydroxycoumarins

Seven-membered ring lactones fused to coumarin scaffolds were obtained via a palladium-catalyzed regioselective intramolecular alkoxycarbonylation under a CO atmosphere. Cyclocarbonylation of 3-allyl-4-hydroxycoumarin derivatives was accessed in the absen

Annulation of β-naphthols and 4-hydroxycoumarins with vinylsulfonium salts: Synthesis of dihydrofuran derivatives

A new synthetic approach to dihydrofuran derivatives via the annulation reaction of β-naphthols and 4-hydroxycoumarins with vinylsulfonium salts has been developed. A variety of dihydrofuran derivatives were prepared in moderate to good yields under mild conditions. The products could be readily transformed to the corresponding furans via the dehydrogenation with DDQ.