19942-02-0

Basic information

• Product Name: Olean-12-ene-3β,16β,21β,23,28-pentol
• Synonyms: Gymnestrogenin;Olean-12-ene-3β,16β,21β,23,28-pentol;(3beta,4alpha,16beta,21beta)-Olean-12-ene-3,16,21,23,28-pentol;Olean-12-ene-3beta,16beta,21beta,23,28-pentol
• CAS NO: 19942-02-0
• Molecular Formula: C₃₀H₅₀O₅
• Molecular Weight: 490.715
• Mol File: 19942-02-0.mol

Chemical Properties

• Melting Point: 288-289℃
• Appearance: /
• CAS DataBase Reference: Olean-12-ene-3β,16β,21β,23,28-pentol(CAS DataBase Reference)
• NIST Chemistry Reference: Olean-12-ene-3β,16β,21β,23,28-pentol(19942-02-0)
• EPA Substance Registry System: Olean-12-ene-3β,16β,21β,23,28-pentol(19942-02-0)

Safety Data

• Hazardous Substances Data: 19942-02-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Olean-12-ene-3β,16β,21β,23,28-pentol is used as a therapeutic agent for its potential anti-inflammatory, anti-cancer, and anti-diabetic properties. Its diverse biological activities make it a promising candidate for the development of new drugs to treat various health conditions.
Used in Liver Health Supplements:
Olean-12-ene-3β,16β,21β,23,28-pentol is used as a hepatoprotective and antioxidant supplement to support liver health and reduce the risk of liver-related diseases. Its ability to protect the liver from damage and promote its overall function makes it a valuable ingredient in liver health supplements.
Used in Cholesterol-Lowering Products:
Olean-12-ene-3β,16β,21β,23,28-pentol is used as a cholesterol-lowering agent to help reduce high cholesterol levels and maintain cardiovascular health. Its potential to lower cholesterol levels makes it a beneficial component in dietary supplements and functional foods aimed at promoting heart health.
Used in Anti-Aging Products:
Olean-12-ene-3β,16β,21β,23,28-pentol is used as an anti-aging agent in skincare and cosmetic products due to its antioxidant properties. Its ability to protect the skin from oxidative stress and promote skin health makes it a valuable ingredient in anti-aging formulations.
Used in Traditional Medicine:
Olean-12-ene-3β,16β,21β,23,28-pentol has been used in traditional medicine for its hepatoprotective, antioxidant, and anti-aging effects. Its long history of use and potential health benefits make it a valuable component in various traditional medicine formulations and practices.

Upstream product

• 107110-02-1 Benzoic acid (3S,4aS,5S,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-3,10-dihydroxy-4a,9-bis-hydroxymethyl-2,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydro-picen-5-yl ester 
• 121686-42-8 3-O-β-D-glucuronopyranosyl gymnemagenin 

Relevant articles and documents

Triterpene saponins from Pleurospermum kamtschaticum and their biological activity

Eleven new triterpene saponins (1-11), together with fourteen known triterpene and triterpene saponins (12-25) were isolated from a MeOH extract of Pleurospermum kamtschaticum HOFFMANN (Umbelliferae). The chemical structures of the new compounds (1-11) were determined by means of MS, 1H-NMR, 13C-NMR, correlated spectroscopy (COSY), heteronuclear multiple bond correlation (HMBC), total correlated spectroscopy (TOCSY) and nuclear Overhauser effect spectroscopy (NOESY) to be pleurosaponin A (1)-K (11). The isolated compounds were tested for their cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, HCT15) in vitro using the sulforhodamine B bioassay (SRB) assay. All compounds showed little cytotoxicity against tested cell lines (IC50 >30 μM).

Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists

The individual chemical components of commercial extract of Gymnema sylvestre, a medicinal plant used in the traditional systems of the Indian medicine for its antidiabetic and hypolipidemic properties, were isolated and evaluated for their capability to act as modulators of nuclear and membrane receptors involved in glucose and lipid homeostasis. The study disclosed for the first time that individual gymnemic acids are potent and selective antagonists for the β isoform of LXR. Indeed the above activity was shared by the most abundant aglycone gymnemagenin (10) whereas gymnestrogenin (11) was endowed with a dual LXRα/β antagonistic profile. Deep pharmacological investigation demonstrated that gymnestrogenin, reducing the expression of SREBP1c and ABCA1 in vitro, is able to decrease lipid accumulation in HepG2 cells. The results of this study substantiate the use of G. sylvestre extract in LXR mediated dislypidemic diseases.

GLOCHIDIOSIDE, A TRITERPENE GLYCOSIDE FROM GLOCHIDION HEYNEANUM

Key Word Index - Glochidion heyneanum; Euphorbiaceae; triterpenoid glycoside; glochidioside.A new triterpenoid glycoside, glochidioside, has been isolated from Glochidion heyneanum.Its structure has been established as 3β 3)-O-α-L-arabinopyranosyl)oxy>-16β-benzoyloxy-olean-12-ene-21β,23,28-triol by chemical and spectroscopic mehtods.