199458-24-7

Basic information

• Product Name: Toluene-4-sulfonic acid (R)-2-hydroxy-2-[(3aR,5R,6R,6aR)-6-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethyl ester
• Synonyms: Toluene-4-sulfonic acid (R)-2-hydroxy-2-[(3aR,5R,6R,6aR)-6-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethyl ester
• CAS NO: 199458-24-7
• Molecular Weight: 494.563
• Mol File: 199458-24-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Toluene-4-sulfonic acid (R)-2-hydroxy-2-[(3aR,5R,6R,6aR)-6-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Toluene-4-sulfonic acid (R)-2-hydroxy-2-[(3aR,5R,6R,6aR)-6-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethyl ester(199458-24-7)
• EPA Substance Registry System: Toluene-4-sulfonic acid (R)-2-hydroxy-2-[(3aR,5R,6R,6aR)-6-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethyl ester(199458-24-7)

Safety Data

• Hazardous Substances Data: 199458-24-7(Hazardous Substances Data)

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 69940-02-9 3-O-(4-Methoxybenzyl)-1,2:5,6-di-O-isopropylidene-α-D-allofuranose 
• 14686-89-6 (1,2:5,6)-di-O-isopropylidene-D-gulose 
• 69940-04-1 (R)-1-[(3aR,5R,6R,6aR)-6-(4-methoxybenzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 199458-13-4 1-[(2R,3R,4R,5R)-5-((S)-1-Azido-ethyl)-3-methoxy-4-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-3-(4-methoxy-benzyloxymethyl)-5-methyl-1H-pyrimidine-2,4-dione 
• 199458-26-9 Toluene-4-sulfonic acid (R)-1-[(3aR,5S,6R,6aR)-6-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethyl ester 
• 199458-29-2 Acetic acid (3R,4R,5R)-2-acetoxy-5-((S)-1-azido-ethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yl ester 
• 199458-27-0 (3aR,5R,6R,6aR)-5-((S)-1-Azido-ethyl)-6-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole 
• 199458-25-8 (R)-1-[(3aR,5R,6R,6aR)-6-(4-Methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethanol 

Relevant articles and documents

Amide-Modified Oligonucleotides with Preorganized Backbone and Furanose Rings: Highly Increased Thermodynamic Stability of the Duplexes Formed with their RNA and DNA Complements

The amide backbone modification C3′-CH2-CONH-C5′ has been further modified by introducing a methyl at C5′, either in R or in S configuration. Only the S stereoisomer can adopt the required geometry to fit into a duplex with complementary RNA. A