199484-66-7Relevant academic research and scientific papers
Synthesis and characterization of SAMs and tethered bilayer membranes from unsymmetrically substituted 1,2-dithianes
Burns, Christopher J.,Field, Leslie D.,Petteys, Brian J.,Ridley, Damon D.
, p. 738 - 748 (2005)
The synthesis of a series of new membrane-forming compounds, based on previously established components used in an ion-channel switch (ICS) biosensor (Nature 1997, 387, 580) is described. All new compounds are derived from 4,5-dihydroxy-1,2-dithiane, and contain a hydrophilic reservoir section (based on ethylene glycol units) and a lypophilic section (based on the natural lipid phytanol). Ellipsometry and contact angle measurements indicate that self-assembled monolayers (SAMs) formed from the new materials possess thicknesses and membrane packing comparable to previously reported biosensor components. Tethered bilayer lipid membranes (t-BLMs) incorporating the novel materials were studied using impedance spectroscopy with the ion-carrier valinomycin. The electrical behavior and calculated membrane thickness of the t-BLMs are comparable to those derived from the standard ICS components and this demonstrates that the novel membrane-forming compounds form stable membranes that are sufficiently fluid to transport potassium ions in the presence of valinomycin. CSIRO 2005.
Water-soluble nile blue derivatives: syntheses and photophysical properties
Jose, Jiney,Ueno, Yuichiro,Burgess, Kevin
supporting information; experimental part, p. 418 - 423 (2009/06/19)
Four water-soluble 2-hydroxy-Nile Blue derivatives, 1a, 1b, 2a, and 2b, were prepared by condensation reactions performed under relatively mild conditions (90°C, N,N-dimethylformamide with no added acid). These fluorescent probes had more favorable fluorescence characteristics than two known water-soluble Nile Blue derivatives. Specifically, they were superior to the known dyes with respect to their quantum yields in aqueous media and the sharpness of their fluorescence emissions. Concentration-dependant UV absorption and fluorescence emission studies indicated that the dyes did not aggregate in aqueous solution at concentrations of less than 1-4 μM. The new water-soluble materials 1a, 1b, 2a, and 2b emit in a desirable region of the fluorescence spectrum (A = 670-675 nm). Overall they are potentially interesting for labeling biomolecules in aqueous environments.
