1995-49-9Relevant academic research and scientific papers
One-pot synthesis of 3,5-disubstituted and polysubstituted phenols from acyclic precursors
Qian, Jinlong,Yi, Wenbin,Huang, Xin,Miao, Yongbo,Zhang, Junkai,Cai, Chun,Zhang, Wei
supporting information, p. 1090 - 1093 (2015/03/14)
A new strategy for the synthesis of 3,5-disubstituted phenols is established through one-pot Robinson annulation of α,β-unsaturated ketones with α-fluoro-β-ketoesters followed by in situ dehydrofluorination and tautomerization. This method has been extended to the synthesis of polysubstituted phenols and applied in the preparation of biologically active compounds.
