19950-28-8Relevant academic research and scientific papers
Reactivity of 2-aminothiazole and 2- or 6-aminobenzothiazole derivatives towards the triphenylbismuth diacetate/catalytic copper diacetate phenylation system
Miloudi, Abdellah,El-Abed, Douniazad,Boyer, Gerard,Finet, Jean Pierre,Galy, Jean Pierre,Siri, Didier
, p. 1509 - 1516 (2004)
The copper diacetate catalysed reaction of triphenylbismuth diacetate with 6-aminobenzothiazole compounds afforded selectively the 6-phenylamino derivatives in good to high yields. A similar reaction with 2-aminothiazole or 2-amino-benzothiazole compounds gave mixtures of the monophenylated and diphenylated products 2-phenylaminothiazole and 2-(N-phenylamino)-3-N′- phenylthiazole derivatives, respectively, with the diphenyl product being predominant. Semi-empirical calculations with the SAM1/D and CHAIN methods performed on the evolution of a 2-aminobenzothiazole - copper(III) intermediate were in good qualitative agreement with the experimental results. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
ACETIC ACID AMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY ON VASCULAR ENDOTHELIAL LIPASE
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Page/Page column 67, (2011/08/08)
Disclosed is a compound which is useful as an endothelial lipase inhibitor. A pharmaceutical composition having inhibitory activity on endothelial lipase comprising a compound represented by the formula: , its pharmaceutically acceptable salt, or a solvate thereof, wherein Ring A is nitrogen-containing hetero ring, Ring A may be substituted with a substituent other than a group represented by the formula: -C(R1R2)-C(=O)-NR3R4 and a group represented by the formula: -R5, a broken line represents the presence or the absence of a bond, Z is -NR6-, =N-, -O-, or -S-, R6 is halogen, substituted or unsubstituted alkyl or the like, R1 and R2 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy or substituted or unsubstituted alkyl, R3 is hydrogen or substituted or unsubstituted alkyl, R4 is hydrogen, substituted or unsubstituted alkyl or the like, R3 and R4 taken together with the adjacent nitrogen atom to which they are attached may form a substituted or unsubstituted ring, R5 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like.
