199540-03-9Relevant academic research and scientific papers
A highly enantioselective synthesis of cyclic α-amino acids involving a one-pot, single catalyst, tandem hydrogenation-hydroformylation sequence
Teoh, Euneace,Campi, Eva M.,Roy Jackson,Robinson, Andrea J.
, p. 978 - 979 (2002)
Tandem enantioselective hydrogenation followed by a hydroformylation-cyclisation sequence leading to cyclic α-amino acids with ee's > 95% can be achieved in a single pot, one catalyst system by successive reactions of prochiral dienamide esters with H2 followed by H2/CO using Rh(I)DuPHOS.
One-pot tandem enantioselective hydrogenation-hydroformylation synthesis of cyclic α-amino acids
Teoh, Euneace,Campi, Eva M.,Jackson, W. Roy,Robinson, Andrea J.
, p. 387 - 394 (2007/10/03)
Five- and six-membered cyclic amino acids can be prepared in good yield with high ee (> 95%) via tandem rhodium-DuPHOS catalysed asymmetric hydrogenation followed by a rhodium-catalysed hydroformylation-cyclisation sequence in a single pot. The synthesis can be achieved using Rh-DuPHOS as the sole catalyst.
