199612-67-4

Upstream product

• 767-91-9 1-ethynyl-2-methoxybenzene 
• 199612-66-3 3-methoxy-5-methyl-2-[(trimethylsilyl)ethynyl]benzaldehyde 
• 529-28-2 4-iodoanisol 
• 1066-54-2 trimethylsilylacetylene 
• 40230-91-9 [(2-methoxyphenyl)ethynyl]trimethylsilane 
• 887399-67-9 1-[2-(3-hydroxy-3-methylbut-1-ynyl)-3-methoxy-5-methylphenyl]-3-(2-methoxyphenyl)prop-2-yn-1-one 
• 887399-66-8 4-{2-[1-hydroxy-3-(2-methoxyphenyl)prop-2-ynyl]-6-methoxy-4-methylphenyl}-2-methylbut-3-yn-2-ol 
• 887399-65-7 1-(2-iodo-3-methoxy-5-methylphenyl)-3-(2-methoxyphenyl)prop-2-yn-1-ol 
• 199612-65-2 2-iodo-3-methoxy-5-methylbenzaldehyde 

Downstream Products

• 199612-68-5 diphenyl[3-(5-methyl-3-methoxy-2-trimethylsilylethynylphenyl)-1-(2-methoxyphenyl)-1,2-propadienyl]oxophosphorane 
• 887399-71-5 1-(2-ethynyl-3-methoxy-5-methylphenyl)-3-(2-methoxyphenyl)prop-2-yn-1-ol 
• 887399-62-4 1-{3-methoxy-5-methyl-2-[2-(trimethylsilyl)ethynyl]phenyl}-3-(2-methoxyphenyl)prop-2-yn-1-one 

Relevant academic research and scientific papers

Synthesis of the benzo[b]fluorene core of the kinamycins by arylalkyne-allene and arylalkyne-alkyne cycloadditions

Arylalkyne-allene and arylalkyne-alkyne cycloadditions yields benzo[a]fluorenones, which are related to the tetracyclic core of the kinamycins. In the arylalkyne-alkyne cycloadditions, we found a rearrangement that produces benzo-[a]fluorenones, in addition to the expected benzo[b]fluorenones. This rearrangement could be suppressed in the presence of phenol, which allowed the synthesis of 4,9-dimeth-oxy-2-methyl-11H-benzo[b] fluoren-11-one in excellent yield. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

An approach to the synthesis of the benzo[b]fluorene core of the kinamycins by an arylalkyne-allene cycloaddition

The cyclization of an arylalkyne to an allene followed by ring closure was applied for the ready construction of the tetracyclic core of the kinamycin family of antibiotics.