199678-95-0Relevant academic research and scientific papers
Regioselective enzymatic β-carboxylation of para-hydroxy-styrene derivatives catalyzed by phenolic acid decarboxylases
Wuensch, Christiane,Pavkov-Keller, Tea,Steinkellner, Georg,Gross, Johannes,Fuchs, Michael,Hromic, Altijana,Lyskowski, Andrzej,Fauland, Kerstin,Gruber, Karl,Glueck, Silvia M.,Faber, Kurt
, p. 1909 - 1918 (2015)
Abstract We report on a 'green' method for the utilization of carbon dioxide as C1 unit for the regioselective synthesis of (E)-cinnamic acids via regioselective enzymatic carboxylation of para-hydroxystyrenes. Phenolic acid decarboxylases from bacterial sources catalyzed the β-carboxylation of para-hydroxystyrene derivatives with excellent regio- and (E/Z)-stereoselectivity by exclusively acting at the β-carbon atom of the C=C side chain to furnish the corresponding (E)-cinnamic acid derivatives in up to 40% conversion at the expense of bicarbonate as carbon dioxide source. Studies on the substrate scope of this strategy are presented and a catalytic mechanism is proposed based on molecular modelling studies supported by mutagenesis of amino acid residues in the active site.
PEPTIDE COMPOUNDS WITH TRANSIENT BIODEGRADABLE PEGYLATION
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Page/Page column 46-47, (2008/12/04)
The present invention relates to novel peptides with biodegradable and transient pegylation and of the general formula V, as well as a process for preparing such compounds, and intermediates for use in their preparation. Examples of such compounds include conjugates of GLP-1, exendin, growth hormone, and blood coagulation factor VIII, and the invention also relates to such peptides for use as a medicament, as well as corresponding pharmaceutical compositions. The novel compounds provide drugs with a protracted profile of action.
