199679-82-8

Usage

Uses

Used in Organic Synthesis:
D-Alanine, N-(4-chlorophenyl)-, methyl ester is used as a building block in organic synthesis for designing and synthesizing new drugs. Its unique structure allows it to be a versatile component in the creation of various pharmaceutical compounds.
Used in Pharmaceutical Research:
In pharmaceutical research, D-Alanine, N-(4-chlorophenyl)-, methyl ester serves as a key intermediate for the development of pharmaceutical products with potential biological activities. Its properties make it a valuable asset in the discovery and formulation of novel therapeutic agents.
Used in Chemical and Biochemical Research:
D-Alanine, N-(4-chlorophenyl)-, methyl ester is also a commonly used reagent in both chemical and biochemical research. Its presence in experiments can help scientists understand various chemical reactions and biological processes, contributing to the advancement of scientific knowledge in these fields.

Upstream product

• 123695-95-4 methyl 2-(N-(4-chlorophenyl)amino)propanoate 
• 106-47-8 4-chloro-aniline 
• 99208-98-7 methyl (S)-2-[(trifluoromethanesulfonyl)oxy]propionate 

Downstream Products

• 103678-25-7 (R)-2-(4-Chloro-phenylamino)-propionic acid 

Relevant academic research and scientific papers

Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column

A technique based on liquid chromatography has been developed to facilitate studies of enantioselectivity in penicillin G acylase (PGA)-catalyzed hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues. PGA was covalently immobilized on an aminopropyl monolithic silica support to create an immobilized HPLC-enzyme reactor. Two sets of experimental data were drawn to calculate the enantioselectivity (E) of the kinetically controlled enantiomer-differentiating reaction, the degree of substrate conversion and the enantiomeric excess of the product. The developed enzymatic reactor was coupled through a switching valve to an achiral analytical column for separation and quantitation of the hydrolysis products. The enantiomeric excess was determined off-line on a PGA-chiral stationary phase. In this way, highly precise E values were determined. A computational study related to the hydrolysis of the considered racemic esters was also carried out in order to unambiguously clarify both the substrate specificity and the enantioselectivity displayed by PGA.

Isosteres of chiral clofibric acid analogs: Synthesis, resolution, absolute configuration and HPLC detection of the optical purity

Both racemic and enantiomeric forms of some isosteres of chiral clofibric acid analogs have been synthesized. Also, the absolute configuration has been established by chemical correlation and the optical purity determined by a simple HPLC procedure. Moreover, these studies show that the isosteric substitution of the ether oxygen atom of α-aryloxy- alkanoic acids with sulfur, amino and methylene groups lead to compounds in which both biological activity and stereoselectivity regarding chloride channel are highly reduced.