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2,2,2-Trifluoro-N-(2-nitro-5-(trifluoromethyl)phenyl)acetamide is a complex organic compound with the molecular formula C9H4F6N2O4. It is characterized by the presence of three fluorine atoms attached to the central carbon atom, a nitro group (NO2) at the 2-position, and a trifluoromethyl group (CF3) at the 5-position of the phenyl ring. The acetamide group (-COCH3) is connected to the nitrogen atom, forming an amide bond. 2,2,2-trifluoro-N-(2-nitro-5-(trifluoromethyl)phenyl)acetamide is known for its potential applications in pharmaceuticals and agrochemicals due to its unique chemical structure and properties. It is important to note that handling and use of such compounds should be done with caution, as they may have specific safety and environmental considerations.

1997-46-2

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1997-46-2 Usage

Molecular weight

326.16 g/mol

Physical form

White powder

Melting point

132-135°C

Use in industry

Intermediate in the synthesis of potential drug candidates

Application

Medicinal chemistry research and drug development

Potential

Biological activity and pharmacological properties

Usage

Building block in the synthesis of other organic compounds with potential pharmaceutical applications

Check Digit Verification of cas no

The CAS Registry Mumber 1997-46-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,9 and 7 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1997-46:
(6*1)+(5*9)+(4*9)+(3*7)+(2*4)+(1*6)=122
122 % 10 = 2
So 1997-46-2 is a valid CAS Registry Number.

1997-46-2Relevant academic research and scientific papers

Synthesis and antiprotozoal activity of some 2-(trifluoromethyl)-1H- benzimidazole bioisosteres

Navarrete-Vazquez, Gabriel,Rojano-Vilchis, Maria De Monserrat,Yepez-Mulia, Lilian,Melendez, Victor,Gerena, Lucia,Hernandez-Campos, Alicia,Castillo, Rafael,Hernandez-Luis, Francisco

, p. 135 - 141 (2006)

A series of 2-(trifluoromethyl)-1H-benzimidazole derivatives with various 5- and 6-position bioisosteric substituents (-Cl, -F, -CF3, -CN), namely 1-7, were prepared using a short synthetic route. Each analogue was tested in vitro against the protozoa Giardia intestinalis and Trichomonas vaginalis in comparison with albendazole and metronidazole. Several analogues had IC50 values 1 μM against both species, which make them significantly more potent than either standard. Compound 4 [2,5(6)- bis(trifluoromethyl)-1H-benzimidazole], was 14 times more active than albendazole against T.:vaginalis. This compound (4) also showed moderate antimalarial activity against W2 and D6 strains of Plasmodium falciparum (5.98 and 6.12 μM, respectively). Studying further structure activity relationships through the use of bioisosteric substitution in these benzimidazolic derivatives should provide new leads against protozoal and possibly malarial diseases.

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