199737-03-6Relevant academic research and scientific papers
Kinetic resolution of racemic halohydrins, precursors of optically active di- and trialkyl-substituted epoxides, with lipase from Pseudomonas sp.
Adam, Waldemar,Blancafort, Lluis,Saha-Moeller, Chantu R.
, p. 3189 - 3192 (1997)
Asymmetric acetylation of racemic halohydrins with vinyl acetate catalyzed by lipase from Pseudomonas sp. afforded the optically active β-halo alcohols 1 and acetates 2 in high enantiomeric excess (68 to >98%). The enzymatic kinetic resolution was performed on the preparative scale and the halo alcohols 1 and acetates 2 led to the optically active epoxides 3 after base treatment.
