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Paliperidone Palmitate
Cas No: 199739-10-1
No Data No Data No Data Koning Pharmchem Co., Ltd. Contact Supplier
Paliperidone Palmitate ER injectable suspension
Cas No: 199739-10-1
No Data 1 Gram 1000 Metric Ton/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
Paliperidone palmitate CAS:199739-10-1 Safe delivery Free of customs clearance
Cas No: 199739-10-1
USD $ 1.0-10.0 / Kilogram 1 Kilogram 5000 Kilogram/Month WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
High Quality API CAS 199739-10-1 Paliperidone Palmitate powder
Cas No: 199739-10-1
USD $ 20.0-35.0 / Gram 10 Gram 5000 Kilogram/Month Xi'an Julong Bio-Tech Co., Ltd. Contact Supplier
Paliperidone palmitate
Cas No: 199739-10-1
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Paliperidone palmitate
Cas No: 199739-10-1
USD $ 1.0-2.0 / Gram 10 Gram 100 Kilogram/Day Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
New production CAS 199739-10-1 with best quality
Cas No: 199739-10-1
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
BLOOM TECH Advanced API/Technology support Paliperidone Palmitate CAS 199739-10-1
Cas No: 199739-10-1
No Data 1 Gram 3 Metric Ton/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier
Paliperidone Palmitate hot sale
Cas No: 199739-10-1
USD $ 10.0-1000.0 / Gram 10 Gram 8000 Kilogram/Month HUBEI AOKS BIO-TECH CO.,LTD Contact Supplier
Paliperidone Palmitate [USAN] 199739-10-1
Cas No: 199739-10-1
No Data 1 Kilogram 10000 Metric Ton/Month Shanghai Upbio Tech Co.,Ltd Contact Supplier

199739-10-1 Usage

Uses

A long-acting injectable atypical antipsychotic used in the treatment of schizophrenia.

199739-10-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Paliperidone Palmitate

1.2 Other means of identification

Product number -
Other names 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido-[1,2-a]pyrimidin-4-one palmitate ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:199739-10-1 SDS

199739-10-1Synthetic route

palmitic anhydride
623-65-4

palmitic anhydride

paliperidone
144598-75-4

paliperidone

paliperidone palmitate
199739-10-1

paliperidone palmitate

Conditions
ConditionsYield
Stage #1: palmitic anhydride; paliperidone With dmap In toluene at 20 - 70℃; for 3h;
Stage #2: With tert-butyl methyl ether In toluene at 10℃; for 1h; Product distribution / selectivity;
88.5%
1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

paliperidone
144598-75-4

paliperidone

paliperidone palmitate
199739-10-1

paliperidone palmitate

Conditions
ConditionsYield
With dmap; pivaloyl chloride; triethylamine In tetrahydrofuran at 20℃; for 24h; Product distribution / selectivity;80%
3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one palmitate ester
1415488-05-9

3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one palmitate ester

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

paliperidone palmitate
199739-10-1

paliperidone palmitate

Conditions
ConditionsYield
Stage #1: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With potassium carbonate In acetonitrile at 25 - 60℃; for 1.16667h;
Stage #2: 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one palmitate ester With tetrabutylammomium bromide; potassium iodide at 20 - 75℃; for 14h;
80%
Stage #1: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With potassium carbonate In acetonitrile at 25 - 60℃; for 1.16667h;
Stage #2: 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one palmitate ester With tetra-(n-butyl)ammonium iodide; potassium iodide In acetonitrile at 25 - 75℃; for 16h;
80%
paliperidone
144598-75-4

paliperidone

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

paliperidone palmitate
199739-10-1

paliperidone palmitate

Conditions
ConditionsYield
Stage #1: paliperidone With sodium hydride In N,N-dimethyl-formamide at 0℃;
Stage #2: n-hexadecanoyl chloride In N,N-dimethyl-formamide at 0℃; for 5h; Product distribution / selectivity;
53.1%
With dmap; triethylamine In dichloromethane at 15℃; for 8h; Temperature;
3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one sodium
1172995-09-3

3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one sodium

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

paliperidone palmitate
199739-10-1

paliperidone palmitate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 2h;10 %Chromat.
1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

paliperidone palmitate
199739-10-1

paliperidone palmitate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dmap; triethylamine / dichloromethane / 0.25 h / 25 - 30 °C
1.2: 2 h / 25 - 40 °C
2.1: potassium carbonate / acetonitrile / 1.17 h / 25 - 60 °C
2.2: 14 h / 20 - 75 °C
View Scheme
paliperidone palmitate
199739-10-1

paliperidone palmitate

paliperidone
144598-75-4

paliperidone

Conditions
ConditionsYield
Stage #1: paliperidone palmitate With hydrogenchloride In water at 75 - 80℃; for 2h;
Stage #2: With sodium hydroxide In methanol; dichloromethane; water; isopropyl alcohol at 10 - 30℃; for 1h; pH=10 - 12; Reflux;
90%
With hydrogenchloride In water at 75 - 80℃; for 2h;90%
paliperidone palmitate
199739-10-1

paliperidone palmitate

A

3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7-dihydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
913728-82-2

3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7-dihydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

B

3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-9-pentadecyl-4H-pyrido[1,2-a]pyrimidin-4-one
913728-83-3

3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-9-pentadecyl-4H-pyrido[1,2-a]pyrimidin-4-one

C

paliperidone
144598-75-4

paliperidone

Conditions
ConditionsYield
Product distribution / selectivity; X-irradiation;

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